Sentences with phrase «deficient gene mutation»

Not exact matches

Mice that carry a homozygous missense mutation in the Csf1 gene (Csf1op / op) are relatively macrophage deficient (43, 54, 55).

The reason they're deficient is that they have a non-sense mutation in the leptin gene, and this leads to a lack of the satiety factor, and therefore these animals are constantly hungry and are hyperphagic.

We found that mutation accumulation in organoids deficient in the mismatch repair gene MLH1 is driven by replication errors and accurately models the mutation profiles observed in mismatch repair - deficient colorectal cancers.