Sentences with phrase «deficient humans and mice»

Not exact matches

A decade ago, he replicated the entire human leukemia disease process by introducing oncogenes into normal human blood cells, transplanting them into xenografts (special immune - deficient mice that accept human grafts) and watching leukemia develop — a motherlode discovery that has guided leukemia research ever since.

Because of altered Fgfr2 splicing, cells of the stria vascularis are missing in Esrp1 - deficient mice, and possibly in humans.

We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean mice and humans to over 50 % in extremely obese, leptin - deficient mice and nearly 40 % in obese humans.

In their study «D - Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain,» the lab utilized SR deficient (SR - / --RRB- mice, which have < 15 % of normal D - serine levels, to validate and optimize a D - serine immunohistochemical method.

For the study, the researchers treated part of a human artery — a few millimeters in diameter — with the siRNA - loaded nanoparticles and transplanted it into the abdominal aorta of an immune - deficient mouse inoculated with human T cells.

Interestingly, the Salk researchers found that satellite de-repression was observed in both mouse and human BRCA1 - deficient breast cancers, and that restoration of BRCA1 repressed expression of the satellite genes by about 20-fold.

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

We first evaluate the Neu5Gc content of various foods to show that red meats are particularly rich in orally bioavailable Neu5Gc and then investigate human - like Neu5Gc - deficient mice fed this form of Neu5Gc.