Sentences with phrase «deficient mice»

When looking at the bone cells in a culture dish, the receptor deficient mice did show 80 percent less lipid storage than regular mouse models of aging.

Nevertheless, selenium - deficient mice experienced more serious symptoms, such as lung damage, than did other mice.

Acute alcohol - treated FOXO3 - deficient mice developed more severe liver injury than that of wild - type mice, and this was attributed to decreased expression of autophagy - related genes.

To address this question, the researchers cross-bred SIGMAR1 deficient mice with the other inherited ALS mice which overexpress a mutant form of SOD1 gene.

Increased T - cell Infiltration Elicited by Erk5 Deletion in a Pten - Deficient Mouse Model of Prostate Carcinogenesis.

Gene - deficient mice also exhibit signs of spontaneous inflammatory disease, leading to the hypothesis that 4 - 1BB / 4 - 1BBL interactions also play major regulatory roles which might be manifest at the level of Treg or regulatory APC that promote Treg activity.

We show that vascular smooth muscle cells and blood vessels from estrogen receptor β (ERβ)-- deficient mice exhibit multiple functional abnormalities.

Moreover, the study of deficient mice phenotype for this protein shows that the loss of TREX2 creates a higher susceptibility to UV - induced skin carcinogenesis.

Vascular smooth muscle cells isolated from ERβ - deficient mice show multiple abnormalities of ion channel function.

But when the researchers restored dopamine levels in the dopamine - deficient mice after the mice had received a low dose of morphine, the rodents did show a preference for the morphine - associated chamber.

To test the hypothesis that the immune system causes brain damage after a trauma, the scientists compared the lesion size in CD74 deficient mice, vs control strain after a real brain trauma, with the saline injection.

Another of Woo's experiments involved a PAH - deficient mouse strain developed by William Dove and colleagues at the University of Wisconsin in Madison.

Scharton - Kersten, T., Contursi, C., Masumi, A., Sher, A. & Ozato, K. Interferon consensus sequence binding protein - deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction.

Hyperlipidemia and Atherosclerosclerotic Lesion Development in LDL Receptor - Deficient Mice Fed Defined Semi purified Diets With and Without Cholate.

Duke University Medical Center researchers led by Kyle Allen found that collagen deficient mice prematurely developed common and chronic musculoskeletal disorders while the wild - type mice did not.

Based on such emerging evidence, Dr. Weinman's group fed alcohol to FOXO3 - deficient mice for three weeks.

The immune - deficient mice lost weight, became lethargic and died within 10 days of infection.

Most Alkbh1 deficient mice die during embryonic development, and survivors are characterized by defects in tissues originating from the ectodermal lineage.

The CRF1 - deficient mice exposed to allergic stress had a 54 percent reduction in disease, while those mice who experienced psychological stress had a 63 percent decrease.

Specifically, the metabolic effects of musculoskeletal loading in the current experiments resemble the partial restoration of insulin sensitivity reported in leptin - deficient mice following myostatin ablation (55, 56).

I'm struck by the issue of: a) increased life span in mature mice given HGH b) increased life span in mice with a GH receptor missing c) increase lifespan in GH deficient mice

In ligase deficient mice, growth of mouse melanoma cells in vivo is attenuated, while tumor infiltration by CD4 + / CD8 + T cells and dendritic cells is increased.

Later, using different mice models of psoriasis, they compared the evolution of the disease on normal and deficient mice by TREX2 to infer the function of this molecule.

Dopamine - deficient mice given moderate to high levels of morphine favored the morphine - associated chamber, just like normal mice did, further evidence that dopamine isn't necessary to experience the rewards of morphine, the team reports 8 December in Nature.

In the water T - maze test, which measures spatial learning during acquisition and cognitive flexibility during recall, 16 month - old C3 - deficient mice performed significantly better compared to WT controls.

Finally we examined how the reduced CD4 + DC frequency and defective DC positioning in EBI2 - deficient mice affected CD4 T cell and T - dependent B cell responses.

An obscure biochemist at the NIH, Klaus Schwarz, found that giving selenium to Vitamin E deficient mice protected them from liver degeneration.

The NK1R - deficient mice consumed far less alcohol — especially later in the trial when alcohol concentration was higher — than the normal mice did.

The mice also ate less, were more active, and had milder diabetes symptoms than leptin - deficient mice who received no therapy.

In the new study, Ji's group put SHANK3 - deficient mice through a battery of sensory tests, finding that the animals had lower sensitivity than normal mice to heat and heat - related pain — akin to the soreness a person feels after a sunburn.

Subsequent experiments showed that in normal mice — as in humans — increases in leptin made little difference to the brain, which looked to low leptin levels as a signal to eat more, essentially disregarding the kind of high levels that had caused deficient mice to eat less.

A histologic section of intestinal tissue isolated from healthy Rag1 - deficient mice stained to visualize innate lymphoid cells (RORgt - eGFP, green), intestinal epithelial cells (EpCAM, red) and nuclei (DAPI, blue).

Drs. Merad and Mortha are now developing a multiscale approach to identify GM - CSF downstream targets using macrophages and dendritic cells isolated from GM - CSF deficient mice and exposed to recombinant GMCSF.

The mice were divided into groups that had the different combinations of: CD74 deficient mice vs control mice; a sham brain injury or a real brain injury; and the CAP treatment or a saline injection as a control.

Bone marrow from the p16 - deficient mice made 3 times as many blood - forming stem cells as bone marrow from the normal mice did.

Despite higher glycogen levels, glycogenin - deficient mice underperformed normal mice, reaching exhaustion earlier and covering a shorter distance while running on a treadmill.

In the LOX deficient mice, they observed changes in mechanical behavior and in signaling of groups of genes that appeared to be a susceptibility differentiator in certain sections of tissue; the way they interacted seemed to provide some protection against aneurysm.

To verify that the process worked, the endothelial cells with the inversion - corrected genes were transplanted into F8 deficient mice (mice with hemophilia A) and the mice started producing the F8 clotting factor on their own, which essentially cured them of hemophilia A.

«We found much less DNA methylation in eggs from zinc deficient mice, suggesting that programming of the egg is defective,» Diaz said.

Other published data have already shown that FXR - deficient mice spontaneously develop steatohepatitis and liver tumors even when they are fed a normal rodent diet.

At the advanced age of 20 to 22 months (roughly equivalent to 100 years in humans), the Bax - deficient mice still maintained hundreds of follicles while normal mice had none.

The Bax - deficient mice appeared otherwise normal, Tilly says.

But six of nine PlGF - deficient mice lacked a continuous bone and instead had an unstable, lumpy mass of soft cartilage at the wound site, Carmeliet's team reports today in the Journal of Clinical Investigation.

But three months after the lumican - deficient mouse eyes were injected with human adult corneal stem cells, transparency was restored.

The decreased tumor size and enhanced tumor rejection in DGKζ - deficient mice indirectly suggests that enhanced Erk signaling may be superior to enhanced NF - κΒ activation in facilitating T cell activity against tumor, especially because DKO mice did not exhibit improved tumor control relative to DGKζ − / − mice.

Whereas acute CD8 + T cell effector responses are enhanced in DGKζ - deficient mice postinfection with intracellular pathogens, persistent memory formation is impaired, most dramatically when both DGKζ and DGKα, the other isoform of DGK that metabolizes DAG downstream of the TCR in T cells, are deleted (35, 36).

However, RPE65 gene therapy was found to restore cone function in dogs, and Pang and his colleagues demonstrated that it can restore cone function in Rpe65 - deficient mice if administered early — 14 days after birth (Pang et al. 2006; Pang et al. 2010).