Not exact matches
For both men and women, depression was
defined as having had a prescription of
antidepressant medication, or receiving outpatient / inpatient hospital care, from 12 months before conception to the end of the second trimester of pregnancy.
Incident depression was
defined as reporting a new diagnosis of clinical depression and beginning regular
antidepressant use (in the past 2 years).
Patients were excluded if they (a) were currently receiving psychotherapy or
antidepressant drugs (unless they had been taking the same dose for at least three months without improvement); (b) were unwilling to accept randomisation or were unavailable for follow up; (c) met criteria for severe depression (melancholia) or had a history of bipolar affective disorder, schizophrenia, or substance misuse (
as defined in the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised (DSM - III - R) 18); or (d) were at significant risk of suicide or in need of urgent psychiatric treatment.
Summary: (To include comparison groups, outcomes, measures, notable limitations) Participants were required to have a diagnosis of treatment - resistant depression (TRD), which was
defined as inadequate response to two different appropriately prescribed
antidepressants.