Sentences with phrase «defined cell composition»

Not exact matches

JCAR017 uses a defined CD4: CD8 cell composition and 4 - 1BB as the co-stimulatory signaling domain to mimic a «second signal» that amplifies the activation of CAR T cells, which according to Juno leads to a more robust signal to the T cell to multiply and kill the cancer cell.

The sub-structures are defined by different cell type compositions.

Thirdly, the current, almost universal dependency of organoid culture on the use of Matrigel as a replacement for the function of the extracellular basement matrix in providing structural support and survival signals to the epithelial cells hampers clinical application, considering its origin from a mouse sarcoma cell line, its poorly defined composition and its mechanical rigidity after plating.

JAX researchers at the Bar Harbor - based lab's Farmington, Conn., genomic research facility and collaborators in Singapore defined the composition of cancerous cells from 11 colorectal tumors and their adjacent noncancerous cells.

We build up bio-matrices with defined chemical composition to mimic their environment under physiological and pathological conditions, to supply nutrition, to provide signaling, to create polarized conditions, and to, ultimately, allow us to perform cell - based drug screening in 3D model organs.

First, defined composition of CAR T - cell therapy of non-Hodgkin's lymphoma by Fred Hutchinson Cancer Center.

The cilium has a well - defined structure, which can still accommodate some morphological and molecular composition diversity to suit the functional requirements of different cell types.

New computational strategies are supported by our single cell data analysis experts with computational methods deconvolute tissue composition, determine cell type heterogeneity, identify novel cell type defining markers or track transcriptional dynamics.