Sentences with phrase «definitive endoderm»

The next day, the resulting cells were grown in CDM - PVA supplemented with Ly294002 (10 μM; Calbiochem), Activin (100 ng / ml); FGF2 (40 ng / ml; R&D Systems), and BMP4 (10 ng / ml; R&D Systems) to drive their differentiation toward definitive endoderm.

San Diego, CA (March 31, 2009)-- Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as a cell therapy for diabetes, but also other endoderm lineage - derived tissues and organs such as lungs, intestine, liver, thymus and thyroid.

«This settlement resolves the parties» various patent disputes worldwide with respect to human definitive endoderm cells from human pluripotent stem cells.

ViaCyte's patent portfolio covers many of the intermediary cell types generated when human pluripotent stem cells progress along the differentiation pathway to pancreatic progenitor cells, including mesendoderm and definitive endoderm.

Moreover, as it has recently been shown that VE can contribute to the embryonic gut [55], the distinction between visceral and definitive endoderm begins to blur and the inability of ES cells to contribute to the VE becomes more puzzling.

Immunofluorescence staining of definitive endoderm markers (Foxa2, Sox17 and Gata4) was carried out (c)--(n).

(A) A low concentration of FBS in combination with a high concentration of recombinant Activin A could induce iPS cells of line 11.1 into a definitive endoderm lineage.

(C) When iPS cells were cultured in the absence of the HFF cells, various differentiated cells could be observed, such as definitive endoderm - like cells (a) and (b), fibroblast - like cells (c), cardiomyocytes (d), epidermis - like cells (e) and neural rosettes (f).

For definitive endoderm differentiation, spontaneously formed EBs on day 6 were plated onto matrigel - coated dishes and maintained in a low concentration of fetal bovine serum (FBS) in combination with a high concentration of recombinant Activin A. Scale - like cells appeared (Figure 5A), which were positive for definitive endoderm markers such as Foxa2, Sox17 and Gata4.

The portfolio includes U.S. and foreign patents and applications directed to culture, expansion and scale - up of pluripotent stem cells and cell types derived therefrom, various differentiation processes for production of mesendoderm, definitive endoderm, PEC - 01, and endocrine precursors, as well as claims directed to the Company's Encaptra ® macro-encapsulation device platform.

He is also the lead inventor of many of the Company's key patents, including those encompassing definitive endoderm and

Not exact matches

Novocell scientists pioneered a differentiation process that successfully engineers hES cells into definitive and pancreatic endoderm cells necessary for pancreas formation.