What would be immensely helpful is a drug that could minimize
the degeneration of axons, thus reducing the rate and degree of MS progression.
The new study by researchers at The Neuro shifts the focus to the loss or
degeneration of axons, the nerve - cell «branches» that receive and distribute neurochemical signals among neurons.
Not exact matches
«Treating axonal
degeneration could potentially help a lot
of patients because there are so many diseases and conditions where
axons are inappropriately lost,» says Aaron DiAntonio, MD, PhD, professor
of developmental biology.
Experiments conducted in mice and in human ALS cells reveal that when RIPK1 is out
of control, it can spark axonal damage by setting off a chemical chain reaction that culminates in stripping the protective myelin off
of axons and triggering axonal
degeneration — the hallmark
of ALS.
But a new study by University
of Virginia researchers challenges this idea and suggests that
axons coordinate each other's destruction, thereby contributing to the
degeneration that makes neurological diseases so devastating and permanent.
This means Ind - Cl not only inhibits inflammation but is capable
of reducing
axon degeneration and restoring neuronal function.»
Severing
axons, or axotomy, is a simple way to study the molecular basis
of neurodegeneration as it leads to the activation
of explosive axonal
degeneration.
«Treating axonal
degeneration could potentially help a lot
of patients because there are so many diseases and conditions where
axons are inappropriately lost,» said Aaron DiAntonio, MD, PhD, professor
of developmental biology.
For his research project to explore a novel idea in the field
of neurodegeneration, defining the molecular cascade that controls
axon degeneration, which is a key early event in glaucoma, Dr. Richard Libby was awarded the 2017 Shaffer Prize from Glaucoma Research Foundation.
Metabolic Vulnerability Disposes Retinal Ganglion Cell
Axons to Dysfunction in a Model
of Glaucomatous
Degeneration Baltan, S., Inman DM., Danilov, CA., Morrison, RS., Horner, PJ.
In patients, the peripheral neuropathy is characterized by
degeneration of sensory
axons and is clinically manifested as numbness, pain, and thermohyperesthesia in hands and feet.
Individuals with CMT1 usually show signs
of axon degeneration.