Sentences with phrase «degraded by autophagy»

Neurodegeneration - associated aggregation - prone proteins are predominantly degraded by autophagy and therefore stimulating this process with chemical inducers is beneficial in a wide range of transgenic disease models.

Here we show that SMN protein is degraded by autophagy.

Not exact matches

Endosomes are machinery that tumor cells, via a process called endocytosis, can use to incorporate components into their environment and obtain energy by degrading them via autodigestion or autophagy.

One holds that it is an active process in which paternal mitochondria are selectively degraded by a «self - eating» system known as autophagy, in which vesicles called autophagosomes engulf the cell's unwanted structures.

It has previously been shown to activate a cellular process known as autophagy, which protects against aging by enabling cells to degrade and discard old, damaged «cellular garbage» before it damages cells.

May 12, 2016 Stopping cancer in its tracks Researchers from the University of Chicago have shown that inhibiting autophagy, a self - devouring process used by cells to degrade large intra-cellular cargo, effectively blocks tumor cell migration and breast cancer metastasis in tumor models.

Wang S, Brubaker G, Robinet P, Smith JD, Gulshan K. ORMDL orosomucoid - like proteins are degraded by free cholesterol loading induced autophagy.

Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directions