Sentences with word «degranulation»
Degranulation refers to the process in which cells release tiny particles called granules from within themselves. These granules contain various substances, such as enzymes or chemicals, which are important for the cell's function. When degranulation occurs, these substances are released into the surrounding area, where they can have different effects on other cells or tissues. Full definition
«CHO [carbohydrate] and CHO+VC significantly blunted the post-exercise increase in plasma concentrations of cortisol, ACTH, total leukocyte, and neutrophil counts and limited the decrease in plasma glucose concentration and bacteria - stimulated neutrophil degranulation.»
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Mast cells, which reside in the skin and other tissues, release histamine and other inflammatory chemicals into the bloodstream and surrounding tissue in response to certain stimuli, a process known as degranulation.
It uses quercetin (found in oak trees and alum plants); that stops the initial degranulation process in the mast cells and is a natural anti-histamine; stinging nettles has natural «steroid like» properties and bromelian (from pineapple which acts as a natural anti-inflammatory and helps the quercetin to act faster.
We saw a slight but reproducible decrease in ionomycin - induced degranulation in RhoH − / − BMMCs (Fig. 4 ⇑ A).
FcεRI - stimulated degranulation and cytokine production were impaired in RhoH − / − mast cells.
We think that our data could potentially explain why degranulation occurs as a side effect of opioid ligands (morphine and other drugs), something that is well - known but not well - understood.»
«Receptors in mast cells — part of the immune system — respond to an activation signal and release inflammatory factors like histamine, in a process called degranulation,» she said.
«Opioid drugs have been link to degranulation also, but it was through an unknown mechanism.
In the case of allergy, binding of an allergen to IgE - mast cells results in their rapid degranulation and the release of inflammatory compounds, including histamine, which contribute to local inflammation and the symptoms associated with allergy.
Sensitive and viable identification of antigen - specific CD8 + T cells by a flow cytometric assay for degranulation.
This activates the mast cells in these organs so that they undergo degranulation, releasing ready - made proteases such as chymase and tryptase, and synthesizing inflammatory mediators (leukotrienes and vascular endothelial cell growth factor [VEGF]-RRB-.
The researchers also observed increased tryptase, another marker of mast cell degranulation, in skin around the affected area.
Effects of immediate postexercise carbohydrate ingestion with and without protein on neutrophil degranulation.
It also has an anti-allergic effect, inhibiting the degranulation of mast cells, and thus preventing the release of histamine — the chemical responsible for those typical allergic, running nose and watery eyes symptoms [2].
Next, the scientists plan to study what happens to the alpha subunit post-vibration and to unravel the cellular signaling leading to degranulation.
When the alpha subunit detaches from the beta subunit, the researchers suggest, the beta subunit produces signals inside mast cells that lead to degranulation, which causes hives and other allergy symptoms.
Second, when hu - PBMCs were treated with the IL - 15 superagonist in vitro and subsequently incubated with K562 cells, a well - characterized NK target cell population, the treated NK cells showed increased Cd69 and CD107a expression, markers for activation and degranulation, respectively, compared to untreated hu - PBMCs.
These can then trigger an anti-viral response (left) by releasing the contents of their granules (degranulation) and by upregulating intracellular anti-viral molecules (RIG - I and MDA5).
This pathway is clears threats by initiating inflammatory cytokines, mast cell degranulation, and cell membrane destruction.
Substance P increases sebum production along with mast cell degranulation and a hyperinflammatory response.
Quercetin helps to inhibit the synthesis of enzymes that regulate histamine release and degranulation.
Research has shown that oral consumption of probiotics reduced the vasodilation, edema, mast cell degranulation and TNF - alpha release induced by substance P, compared to the control group.
Stinging Nettle: Stinging nettle leaf has been found to regulate a variety of inflammatory activities associated with hyperimmune response, including mast - cell degranulation, prostaglandin formation and histamine action (20, 21)
CsA and tacrolimus have also been reported to reduce eosinophil production, block mast cell degranulation and suppress tumor necrosis factor cells.
In addition, many owners will report a waxing and waning size of the tumor, which can occur spontaneously, or can be produced by agitation of the tumor, causing degranulation.