A study that took a novel approach to investigating factors affecting the emergence of symptoms of Huntington's disease (HD) has identified at least two genome sites that house variants that can hasten or
delay symptom onset.
So far, we've seen gene silencing drugs tested in several different animal models of Huntington's disease, successfully
delaying symptom onset or even reversing symptoms.
Not exact matches
«If we determine that our [treatment] can prevent or
delay the
onset of
symptoms in healthy yet high - risk populations, this would represent a tremendous breakthrough for those that may face this debilitating disease.»
Depending on athletes to admit to experiencing concussion
symptoms doesn't work due to chronic under - reporting.1 Likewise, studies show that coaches and athletic trainers can't be counted on to reliably identify athletes exhibiting signs of possible concussion for screening on the sports sidelines, especially since only 5 to 10 % of concussions involve a loss of consciousness and the
onset of concussions
symptoms is often
delayed, especially in younger athletes.
It is also important to remember that
symptoms of concussion may not appear until several hours, or even days, after injury (8) with
delayed onset of
symptoms particularly common among younger athletes.
Also, the
onset of the
symptoms can be
delayed in babies and infants.
The benefits of colostrum and breast milk's nutrients will help a baby develop a healthy immune system in general and may help
delay the
onset of
symptoms.
«We found that physical activity has the potential to preserve the volume of the hippocampus in those with increased risk for Alzheimer's disease, which means we can possibly
delay cognitive decline and the
onset of dementia
symptoms in these individuals.
The first clinical trial of a drug intended to
delay the
onset of
symptoms of Huntington disease (HD) reveals that high - dose treatment with the nutritional supplement creatine was safe and well tolerated by most study participants.
A study published in tomorrow's Proceedings of the American Academy of Sciences describes how modified buckyballs — which soak up nerve - destroying chemicals —
delay the
onset of
symptoms in mice suffering from Lou Gehrig's disease.
«Most previous research into ways of
delaying the
onset of HD
symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.
Previous research has shown that many soldiers with initial
symptoms recover soon after, whereas others experience
delayed -
onset symptoms that can go undetected in the first few months after combat.
It's unlikely that we could cure Rett syndrome without addressing the MeCP2 in neurons, but this study provides evidence that by addressing the disease in the immune system we could potentially
delay the
onset of
symptoms,» Litvak said.
There is a
delay of about 10 years between infection and
onset of
symptoms.
Clinical
symptoms developed, but guanabenz administered a week after immunization significantly
delayed the
onset of these
symptoms and reduced peak severity.
Other teams had found that anti-inflammatory drugs may
delay the
onset of
symptoms.
I hope that the new start - up we established on the basis of these findings will enable a drug to be found that can
delay the
onset of cognitive
symptoms in dementia patients and in people with various cognitive impairments,» Prof. Rosenblum concluded.
The study authors previously found out that NF - κB is active in dystrophin - deficient muscle years before the
onset of
symptoms, suggesting that very early treatment of Duchenne Muscular Dystrophy patients with VBP15 may prevent or
delay the
onset of some clinical
symptoms.
The researchers hope that the new start - up they have founded on the basis of the findings will enable the development of a drug that will
delay the
onset of cognitive
symptoms.
They found anti-RGMa antibody
delayed the
onset and attenuated the severity of clinical
symptoms of NMO, suggesting that humanized anti-RGMa antibody is a potentially valid therapeutic approach for NMO.
The AIDS programme's successes include the Concorde trial, which showed that the drug zidovudine (AZT) can not
delay the
onset of AIDS in HIV - positive people without
symptoms, or increase their life expectancy.
The most rational framework with which to discover interventions that prevent or
delay the initial
onset of
symptoms is a biologically based definition of the disease that encompasses both the clinical and the preclinical phases.
The team previously found that NF - κB is active in dystrophin - deficient muscle years before the
onset of
symptoms, suggesting that very early treatment of Duchenne muscular dystrophy patients with VBP15 may prevent or
delay the
onset of some clinical
symptoms.
Targeting apoE4 could
delay or avert the
onset of Alzheimer's disease in people who carry the apoE4 gene, and cease or alleviate
symptoms in those already suffering from the disease.
A new analysis of clinical data from the TRACK - HD and COHORT studies proposes a way to design of clinical trials designed to
delay the
onset of HD, rather than treating
symptoms after they occur.
Onset of
symptoms of CMT is most often in adolescence or early adulthood, however presentation may be
delayed until mid-adulthood.
In SS, there are often long
delays between
symptom onset and definitive diagnosis.
Symptoms are «delayed onset», where symptoms do not appear for hours or ev
Symptoms are «
delayed onset», where
symptoms do not appear for hours or ev
symptoms do not appear for hours or even days.
When I ingest soy proteins or sulfites I have immediate digestive distress followed by a «
delayed»
onset of inflammatory
symptoms about 24 hours later.
In mice engineered to develop Alzheimer's - like
symptoms, alternate - day fasting begun in middle age
delayed the
onset of memory problems by about six months.
Medical anti-aging treatment like BHRT targets the hormones that are causing menopausal
symptoms and can reverse or
delay the
onset of
symptoms.
At the very least, the
symptoms of
delayed -
onset muscle soreness (DOMS) can be mitigated through massage [5].
Thus a
delay of 5 - 10 years may separate the beginning of a vegetarian diet (or absorption problems) and the
onset of deficiency
symptoms.
Low - carbohydrate diets also
delay the
onset of type 2 diabetes, improve the adverse effects of the metabolic syndrome, and ameliorate
symptoms of polycystic ovary disease in women.
BUT, we now know from the PROTECT2 study that in Dobermanns with early - stage DCM (i.e. heart enlargement on ultrasound but no
symptoms of CHF), treatment with pimobendan
delays the
onset of CHF by an average of 9 months.
Most owners realize that rat and mouse bait should not be ingested by their pets, furthermore, most baits have a
delay in
onset of
symptoms.
Treatment for affected individuals may improve their quality of life,
delay the
onset of heart failure
symptoms, and potentially improve life expectancy.
The objective of the treatment is to
delay onset or progression of
symptoms, and to provide maximum quality of life to the dog over the course of the DM.
If you can not afford all or part of the medication / supplements, diet and exercise (at least 2 hours per week) alone may
delay onset of
symptoms or help the dog remain stable.
Begin treatment EARLY for the best chance of
delaying onset of
symptoms.
Furthermore,
symptoms of traumatic brain injury commonly have a
delayed onset, meaning a brain injury victim may not feel the extent of their injuries until weeks later.
Sometimes, injuries can have a
delayed effect or a late
onset of
symptoms depending on the type of injury sustained.
In their developmental account, Hussong et al. (2011) posited that youth who experience high levels of internalizing
symptoms may be
delayed in the
onset of SU, but that once initiated, SU would escalate rapidly.