Sentences with phrase «deleterious point mutations»

In an ideal world, clinicians would be able to remove cells with such deleterious point mutations right after they are created to fight diseases much more effectively.

«We hypothesized that for a given pair of targets that differ by a single point mutation, a set of mismatches could be identified in the guide RNA that would eliminate Cas9's activity on the normal sequence while maintaining robust activity on the one with a deleterious point mutation.

Not exact matches

Every cell line the researchers examined had at least one mutation in its exomic DNA and some of those mutations were potentially deleterious, even oncogenic, Zhang pointed out.