Not exact matches
Her pioneering work mapping the regulatory network of
dendritic cells (DCs) identified a
lineage of DCs that is now considered a key target to improve antiviral and antitumor immunity.
Recently, several observations suggested that, besides monocyte - derived macrophages,
dendritic cells, a distinct myeloid
lineage, also express PPARγ at high levels.
Diagnosis of BPDCN was confirmed by the positivity of the
cells for CD4 and CD56, along with other markers that are more restricted to plasmacytoid
dendritic cells (such as CD123), and the negativity of the
cells for lymphoid, NK and myeloid
lineage - associated antigens.