Our results suggest that the lipid - activated transcription factor PPARγ orchestrates a transcriptional response leading to the development of
a dendritic cell subtype with increased internalizing capacity, efficient lipid presentation, and augmented potential to activate iNKT cells.
Not exact matches
Previous research from the institute revealed there are different
subtypes of
dendritic cells, each primed to recognise certain types of infections.
Dr Florent Ginhoux, Dr Andreas Schlitzer and colleagues from the Singapore Immunology Network (SIgN), a research institute under the Agency for Science, Technology and Research (A * STAR) in Singapore, together with Dr Shalin Naik and Mr Jaring Schreuder from Melbourne's Walter and Eliza Hall Institute, discovered each
subtype of
dendritic cell had its own, unique parent
cell.
«Suppressing a progenitor from creating the
subtype of
dendritic cells implicated in causing lupus, for example, could be an efficient way of treating autoimmune diseases while minimising the impact on the rest of the immune system.
Both memory T
cells subtypes can be reactivated with current immunotherapy treatments, and reactivation of both requires DC1
dendritic cells.