Sentences with phrase «dendritic cell targets»

Not exact matches

Her pioneering work mapping the regulatory network of dendritic cells (DCs) identified a lineage of DCs that is now considered a key target to improve antiviral and antitumor immunity.

When dendritic cells not only signal myelin as a «target substance,» but also secrete the messenger substance IL - 6, a sort of molecular switch is flipped in the T cells.

Another strategy, which Steinman and others were studying, involves a therapy to target dendritic cells inside the body rather than taking them out and personalizing therapy for each patient.

«These results represent a significant advance in our understanding of how commensal microbes can regulate host intestinal immune responses and suggest that the identification of downstream targets in macrophages and dendritic cells along the GM - CSF axis can help the rationale design of novel strategies for the treatment of IBD patients with defective GM - CSF function,» explained Dr. Merad.

Drs. Merad and Mortha are now developing a multiscale approach to identify GM - CSF downstream targets using macrophages and dendritic cells isolated from GM - CSF deficient mice and exposed to recombinant GMCSF.

TIM - 3 is known to play a critical role in regulating the immune system, suggesting that it may be possible to target TIM - 3 on dendritic cells in order to activate T cells.

Moffitt researchers wanted to determine if it would be possible to activate the cancer - fighting properties of T cells indirectly by targeting another type of immune cell called a dendritic cell.

Antibodies only bind to target cells Peptide antibodies developed by Kwak and co-discoverer, Hong Qin, Ph.D., assistant professor of Lymphoma / Myeloma, wipe out MDSCs in the blood, spleen and tumor cells of mice without binding to other white blood cells or dendritic cells involved in immune response.

Gain an understanding of how therapeutic interventions targeting dendritic cells can promote tumor immunity and enhance the efficacy of cancer therapy

However, it is also possible to induce such responses using protein antigens, if there is a signal that promotes cross-presentation and targeting to specific dendritic cell (DC) subsets with the capacity to cross-present antigens.

At the end of his talk, Coukos turned his attention to a dendritic cell vaccine approach in combination with a VEGF - targeting antibody and chemotherapy.

The title of his talk, «Dendritic Cells: A Key Target for Vaccine Science,» focuses on a career - changing finding he was part of three decades ago.

We are developing dendritic cell - based vaccines targeting telomerase, a protein expressed in over 95 percent of cancers and rarely found in normal adult cells.

Immune Design is a clinical - stage biotechnology company made up of collaborative, «can do», experienced professionals passionate about leveraging the company's leading - edge technologies that target dendritic cells for a more precise immune response for the treatment of cancer and other chronic conditions.

Data indicate that Dendritic cells (DC) are an early target for HIV and may become a source of virus for the surrounding cells affecting in turn innate and adaptive immune responses.

Tran T, De Oliveira Diniz M, Dransart E, Gey A, Merillon N, Lone YC, Godefroy S, Sibley C, Ferreira LC, Medioni J, Oudard S, Johannes * L, Tartour * E (2016) A therapeutic Her2 / neu vaccine targeting dendritic cells preferentially inhibits the growth of low Her2 / neu - expressing tumor in HLA - A2 transgenic mice.

The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin — expressed on the surface of such tumors as mesothelioma, ovarian cancer and pancreatic cancer — to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells.

In the experiments described in the paper, the MGH team confirmed that their mesothelin - targeting fusion protein binds to mesothelin on either ovarian cancer or mesothelioma cells, activates dendritic cells, and enhances the cells» processing and presentation of several different tumor antigens, inducing a number of T - cell - based immune responses.

In this system, the dendritic cells are activated and targeted against tumor cells while remaining inside the patient's body.

Blood dendritic cells (DCs) are targeted via a unique sugar structure on their surface.

Ken SHORTMAN, WEHI, Melbourne, AUS «Enhancing protective antibody responses by targeting vaccine antigens to Clec9A on dendritic cells» Host:...

Dendritic cells home to pancreatic and mesenteric lymph nodes and present gliadin, leading to «migration of CD4 − CD8 − γδ and CD4 − CD8 + αβ T cells to the target organ (gut and / or pancreas) where they cause inflammation» (Fasano, 2011).

IMUC's primary candidate targets cancer stem cells via a dendritic cell - based -LSB-...]