Sentences with word «denervation»

We saw no added treatment benefit of renal denervation for patients with severe resistant hypertension who were closely monitored and optimally treated with medications.»

A limitation of the study was that because the aim was to provide evidence of the added value of radiofrequency denervation in a multidisciplinary setting, as done in daily practice, participants and clinicians were not blinded.

No clinically important or statistically significant differences between the groups were shown in the trial assessing radiofrequency denervation for facet joint pain.

(3) Symplicity HTN - 2 Investigators, Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Böhm M. Renal sympathetic denervation in patients with treatment - resistant hypertension (The Symplicity HTN - 2 Trial): a randomised controlled trial.

Renal sympathetic denervation (RDN) has been established as an effective treatment for these patients since 2009.

This pivotal trial is the largest study conducted of renal artery denervation as a treatment for resistant hypertension and the most rigorously designed, including blinding and a sham treatment in the control arm.

During the renal denervation procedure with the Symplicity device used in this trial, a catheter is threaded through arteries to deliver radiofrequency energy that inactivates kidney nerves, interrupting electrical signals to and from the kidney, an organ that performs a major role in regulating blood pressure.

We've shown renal artery denervation is very safe.»

Effects of denervation on acetylcholine receptor clusters on frog cardiac ganglion neurons as revealed by quantitative laser scanning confocal microscopy.

Renal denervation lowered blood pressure when performed at either the early or late stages of hypertension.

Although a particular area of concern was potential renal stenosis, there was only one case in the renal denervation group and none in the sham group.

Although both study groups showed a statistically significant decrease at six months compared with baseline -LRB--14.1 mmHg for renal denervation compared to -11.7 mmHg for the sham treatment control), the difference of -2.29 mmHg in office systolic blood pressure between the two arms was not significant.

«Renal denervation shows no benefit in resistant hypertension.»

Clearly, it is also important to develop a method to assess the completeness of denervation at the time of the procedure.»

However, no measurement method to check for complete denervation in patients exists.

«Renal denervation helps to bring drug - resistant hypertension under control, rat study shows.»

Renal denervation failed to achieve the primary efficacy endpoint of a decrease in systolic blood pressure measured in the doctor's office from baseline to six months or the powered secondary efficacy endpoint of decrease in average 24 - hour levels by ambulatory blood pressure monitoring, which provides more reliable readings.

Renal denervation seems to be more successful at reducing blood pressure in patients with resistant hypertension when it includes accessory renal arteries, according to research recently presented at ESC Congress by Dr Linda Schmiedel from Germany.

In January 2014, Medtronic announced that it was halting its U.S. pivotal trial on renal denervation because the study had failed to reach its primary efficacy endpoint, though it did meet its primary safety endpoint.

«Renal denervation more successful when it includes accessory arteries.»

Renal denervation fell short of primary and secondary efficacy goals in patients with severe resistant hypertension but did meet the primary safety endpoints, according to keenly awaited data from SYMPLICITY HTN - 3 presented at the American College of Cardiology's 63rd Annual Scientific Session.

The major adverse event rate of 1.4 percent for renal denervation comfortably met the safety goal of 9.8 percent, compared with 0.3 percent in the sham treatment arm.

This observation is contrary to clinical trials in humans that supported that the effectiveness of renal denervation depended on blood pressure level, says John Osborn of the University of Minnesota and lead investigator of the study.

Neither bilateral enucleation of the eyes nor sympathetic denervation prevented this light - induced elevation of enzyme activity.

Bilateral consequences of chronic unilateral denervation in the auditory system of the cricket Gryllus bimaculatus.

Katherine Gribble: Expression of the guidance factor semaphorin 2a in the cricket Gryllus bimaculatus following denervation

Because of the extensive serotonergic denervation that has been observed in the AD brain and the important role played by serotonin in both, cognition and behavioural control, this neurotransmitter has become a focus of a research effort to identify new treatments for AD.

Computed Tomography - directed infiltration of the ilio - sacral joint (sacrum or ISG) with denervation via cryotherapy;

Participants in the intervention group received radiofrequency denervation as well, which is usually a 1 - time procedure, but the maximum number of treatments in the trial was three.

During the Symplicity renal denervation procedure, a catheter is threaded through arteries to deliver radiofrequency energy that inactivates kidney nerves, interrupting electrical signals to and from the kidney, an organ that performs a major role in regulating blood pressure.

The researchers found that two trials assessing radiofrequency denervation for the sacroiliac joints and a combination of the facet joints, sacroiliac joints, or intervertebral disks showed a statistically significant but not clinically important improvement in pain intensity three months after the intervention.

«Our study provides a significant contribution to the discussion about renal denervation when considering the procedure for high risk patients who are suffering from uncontrolled hypertension and have exhausted all other options.»

«The findings do not support the use of radiofrequency denervation to treat chronic low back pain from these sources,» the authors write.

In three randomized trials, treatment of chronic low back pain with radiofrequency denervation, a procedure that can be performed with different techniques including the application of an electric current to the pain - conducting nerve, resulted in either no improvement or no clinically important improvement in chronic low back pain, according to a study published by JAMA.

Even though radiofrequency denervation is a commonly used treatment, high - quality evidence for its effectiveness is lacking.

The key implication of this study is that «renal denervation does lower arterial pressure when the denervation is complete,» Osborn says.

This study randomly assigned 535 patients with resistant hypertension and systolic blood pressure of 160 mmHg or higher to renal denervation or angiography alone.

Patients with uncontrolled high blood pressure treated with renal denervation had low rates of adverse events and significant lowering of blood pressure at six months, according to a registry - based study presented at the American College of Cardiology's 63rd Annual Scientific Session.

Most clinical studies have shown that renal denervation can lower high blood pressure in drug - resistant cases, but a number have shown the procedure to be ineffective.

The Global SYMPLICITY Registry is the first and largest dataset of patients with uncontrolled hypertension treated with renal denervation.

«However, we do think research in the field should continue, especially to see if renal denervation is useful in other areas, such as heart failure or with alternative approaches.

Böhm recommends additional research to demonstrate the efficacy of renal denervation and to identify the patient populations who might benefit most from the procedure.

Now, researchers report in the American Journal of Physiology — Regulatory, Integrative and Comparative Physiology that renal denervation — a procedure that disrupts the nerves in the kidneys and prevents them from relaying signals — can treat hypertension, including resistant hypertension, when the nerves are completely blocked.

But researchers at Wake Forest University Baptist Medical Center in Winston?Salem, N.C., found that ALS - affected neurons undergo a process known as «denervation» that severs the connection.

Although renal denervation is in clinical use for uncontrolled hypertension in more than 80 countries, it is still considered an experimental approach in the United States.

Although renal denervation is in clinical use for uncontrolled hypertension in more than 80 countries, it is still an experimental approach in the United States.

«Renal denervation patient registry finds low rate of adverse events.»

«This study shows that renal denervation may be an alternative treatment for uncontrolled hypertension,» said Michael Böhm, M.D., Ph.D., University of Saarland in Homburg, Germany, and lead investigator of the study.