Sentences with phrase «dengue virus»
The phrase "dengue virus" refers to a type of virus that causes the illness known as dengue fever. It is transmitted to humans through the bite of infected mosquitoes and can cause symptoms such as high fever, severe headache, joint and muscle pain, and rash. Full definition
Research Paper In - silico Designing and Testing of Primers for Sanger Genome Sequencing of Dengue Virus Types of Asian Origin Ajay Prakash Joshi, Annette Angel, Bennet Angel, Rajendra Kumar Baharia, Suman Rathore, Neha Sharma, Karuna Yadav, Sharad Thanvi, Indu Thanvi, Vinod Joshi J. Genomics 2018; 6: 34 - 40.
jgenomics.com
In the new work, Luisa Pereira of the Institute for Research and Innovation in Health - University of Porto (i3S), Anavaj Sakuntabhai of Institut Pasteur - Paris and colleagues studied the genetics of 411 patients admitted with dengue virus infection to three hospitals in Thailand between 2000 and 2003.
The authors also had to consider their findings in the context of Dengue virus infection circulating in the local population, which is another viral infection associated with Guillain - Barre.
The study recently published in The American Journal of Tropical Medicine and Hygiene is the first to demonstrate evidence of local transmission of dengue virus in Ghana, rather than exposure being limited to cases brought back from other countries.
If the researchers added a sublethal dose of dengue virus type 2, the resulting infection was fatal.
The novel immunosensor with antibody - nanoparticle hybrid design offers high selectivity and sensitivity for Dengue virus NS1 biomarker diagnosis in sera sample.
The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors.
Chan's interest in immunology began during his childhood in Singapore, which was frequently hit by dengue virus outbreaks.
This pair of «ribbon diagram» images compares the three - dimensional structures of two closely related proteins, determined by X-ray crystallography: (L) the HAP2 protein from the single - celled alga Chlamydomonas reinhardtii and (R) the fusion protein from dengue virus.
A paper on dengue virus infection co-authored by five PNNL researchers was just named one of the 25 percent most - cited articles in the journal PLOS Pathogens.
Rider's potential cure, DRACO, has not been tested against Zika, but it did show effectiveness against the related Dengue virus in cell tests.
«Scientists unravel likely causes of blood vessel leakage in severe dengue: Dengue virus protein may disrupt protective lining of vessels, suggesting potential new treatment targets.»
In tropical regions, Aedes mosquitoes transmit dengue virus (DENV) as well as other closely related viruses such as Zika.
Researchers have struggled to create effective vaccines against dengue virus, in part because four distinct serotypes, or strains, cause the disease and a vaccine must immunize against all four individually.
Outbreak of dengue virus serotype - 2 (DENV - 2) of Cambodian origin in Manipur, India - association with meteorological factors
Mosquito - borne dengue virus (DENV) is a growing public health threat.
This transmission electron micrograph (TEM) depicts a number of round, Dengue virus particles that were revealed in this tissue specimen.
Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination
However, it is also possible that the vaccine might produce antibodies that also recognise other viruses from the same family, like Dengue virus for example.
Professor Young said the spread of four distinct dengue virus types had posed significant hurdles to developing effective vaccines, as any potential vaccine candidate must elicit a strong and protective immune response against all four types.
To create a new dengue virus vaccine, Stefan Metz, Shaomin Tian in the laboratories of Aravinda de Silva, Chris Luft and Joe DeSimone at the University of Carolina, Chapel Hill, USA designed nanoparticles of various shapes and sizes using Particle Replication in Non-wetting Template (PRINT) technology.
«Surprisingly, all three amino acid substitutions rendered [dengue virus] insensitive to AM404, whereas the mutants remained sensitive to ribavirin [another antiviral compound],» the researchers wrote.
Prof. Martin Hibberd: I have no direct conflict of interest, although I do have funding related to Dengue virus sequencing, with funding from various charities and commercial companies such as J&J and recent funding from the MRC Newton fund to sequence Zika viruses in Cape Verde.
Harrison gave examples of what is known about the way viruses such as flu and Dengue virus enter the cell and said that in principle, the mechanisms used by different enveloped viruses to enter cells are quite similar.
Previous laboratory studies have shown that antibodies produced by the human immune system to fight dengue virus can also interact with Zika virus (ZIKV) without inactivating it.
His current research focus is to investigate how Dengue virus interferes with cellular organelles such as mitochondria.
Another, developed by the Butantan Institute in Brazil, taps weakened forms of live Zika virus alongside dengue virus to make a vaccine against Zika, Fauci says.
Exposure to dengue virus triggers a mix of binding and neutralizing antibodies — and ADE requires the mix to be just right.
In the current study, we sequenced 187 new dengue virus serotype 3 (DENV - 3) genotype III whole genomes isolated from Asia and the Americas.
CD4 + cytotoxic T lymphocytes (CD4 - CTLs) were initially identified in patients with chronic viral infections, including dengue virus (DENV) infection, and these cells have been associated with protection in the context of severe DENV infection.
Based on these initial findings, Chotiwan has been able to block dengue virus.
«Our findings should be considered in the development and revision of enhanced [dengue virus] surveillance guidelines,» the researchers say.
«We set out to study why Zika causes microcephaly and related viruses like dengue virus don't,» said Feiran Zhang, PhD, a postdoctoral researcher at Emory University and presenting author on the research.
«This antibody was shown to inhibit but not enhance dengue virus infection and so presents exciting opportunities for control,» Professor Young said.
Katzelnick et al. used antibody - binding data to map structural divergence and antigenic variation among dengue viruses.
Following my PhD, I obtained post-doctoral training under Dr. Alessandro Sette where my efforts were dedicated to characterizing human dengue virus - specific CD8 + and CD4 + T cell in blood samples from areas with endemic dengue infection and following vaccination.
No drugs specifically target dengue virus.
In an effort to identify mutations that would render dengue virus insensitive to AM404 — thereby identifying the compound's target, the researchers tried to generate resistance mutations by culturing the virus in the presence of AM404.
Now, Modhiran et al. and Beatty et al. describe the results of in vitro and in vivo experiments that point to circulating dengue virus non-structural protein 1 (NS1) and the innate immune Toll - like receptor 4 (TLR4) as a focus for basic scientists as well as vaccine and drug developers.
The tropical mosquito is a carrier of the deadly Dengue virus.
«Mosquito saliva increases disease severity following dengue virus infection.»
Using a variety of systems developed in the SMART laboratories in the Campus for Research Excellence And Technological Enterprise (CREATE)(e.g. the SMART humanised mouse model), Duke - NUS and NUS, the team then showed that this novel antibody has the potential to neutralise dengue virus and prevent signs of disease.
Cryo - EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers
The samples were also tested for West Nile Virus, Chagas and Dengue, recombinant Dengue Virus, recombinant Chikungunya Virus, Human Papilloma Virus, Herpes Simplex Virus 1, Herpes Simplex Virus 2, Chlamydia, and Gonorrhea.
A human antibody specific for dengue virus locks viral envelope proteins into a conformation that prohibits viral entry.
[Tyler M. Sharp et al., Fatal Hemophagocytic Lymphohistiocytosis Associated with Locally Acquired Dengue Virus Infection — New Mexico and Texas, 2012] This case is the third locally acquired dengue - related death in the U.S in the last decade (not including Puerto Rico, where dengue is common.)
Researchers have new insights into how protective antibodies attack dengue viruses, which could lead to more effective dengue fever vaccines and drug therapies.
The first report of chikungunya and dengue virus coinfection occurred in 1967, according to the study.
The study also revealed the structural basis of the antibody binding to individual dengue viruses.