As part of our coverage of the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting, held June 2 — 6 in Chicago, we are speaking with Gordon Mills, MD, PhD, chair of
the department of systems biology and professor of medicine and immunology at the University of Texas MD Anderson Cancer Center in Houston, about ways to incorporate homologous recombination markers into clinical practice for ovarian cancer.
Several years ago, I was fortunate to be involved in the founding of the new
department of systems biology at Harvard Medical School and the systems biology graduate program.
Lead author Yarden Katz, a fellow at the center and in
the department of systems biology at Harvard Medical School in Boston, says they were interested in examining the relationship between NIH funding and metrics widely used to indicate scientific quality and determine career advancement, such as publication, citation, and patent counts.
Not exact matches
«The purpose
of the paper was to provide the detailed recipes and protocols so that others can easily duplicate the work and help to further permeate the idea
of «building with
biology» — so that other researchers and educators can have the tools and the knowledge to build these bio-hybrid
systems and attempt to address challenges in health, medicine, and environment that we face as a society,» stated Rashid Bashir, a Grainger Distinguished Chair in Engineering and head
of the
Department of Bioengineering at Illinois.
The approach combined experimental synthetic
biology led by Mark Isalan, now Reader in Gene Network Engineering at the
Department of Life Sciences
of Imperial College London with computational modelling led by James Sharpe, ICREA Research Professor and head
of the Multicellular
Systems Biology lab at the CRG.
«Mantis shrimp, or stomatopods, are well known for aggressive temperaments and complex visual
systems, but until now we've known very little about whether and how they use color to communicate with other mantis shrimp,» said Amanda Franklin, a Ph.D. student in the
biology department of Tufts University's Graduate School
of Arts and Sciences and the first and corresponding author on the paper.
«What was really cool about this research was we've known for a long time that a lot
of different transcription factors were involved, but it was hard to understand how all the pieces fit together,» said Jenny Mortimer, director
of plant
systems biology at the Joint BioEnergy Division, a part
of the
Department of Energy.
«Earlier studies have shown that vitamin E can help regulate the aging body's immune
system, but our present research is the first study to demonstrate that dietary vitamin E regulates neutrophil entry into the lungs in mice, and so dramatically reduces inflammation, and helps fight off infection by this common type
of bacteria,» said first author Elsa N. Bou Ghanem, Ph.D., postdoctoral scholar in the
department of molecular
biology and microbiology at Tufts University School
of Medicine (TUSM).
«We're trying to tease apart a largely unknown area
of biology,» said
systems biologist Josh Adkins and team lead at the
Department of Energy's Pacific Northwest National Laboratory.
Researchers from immune
biology professor Annette Oxenius's group have now discovered what keeps NK cells from killing off their «colleagues from the other
department»
of the immune
system: healthy CD8 + cells are able to detect the immune messenger substance type 1 interferon, which binds to specific receptors on the surface
of these immune cells and thereby conceals their stress.
The relocation
of the University's Howard Hughes Medical Institute from the Peck Pavilion to the IRB will, for example, support a new project in which Susan Lindquist, PhD, Albert D. Lasker professor
of molecular genetics and cell
biology and Howard Hughes Investigator, and researchers from the
departments of chemistry and physics will use the inherent complexity and diversity found in biological
systems to develop new functional materials.
We established specific interfaces with the
departments of cell
biology and bioinformatics /
systems biology.
Systems biology of bone,
Department of Mouse and Zebrafish Genetics, Wellcome Trust Sanger Institute, Cambridge, CB10 1SA, United Kingdom.