Sentences with phrase «dependent deacetylase»

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

Specifically, the researchers found that rutin directly binds to and stabilizes SIRT1 (NAD - dependent deacetylase sirtuin - 1), leading to hypoacetylation of PGC1α protein, which stimulates Tfam transactivation and eventually augments mitochondrial number and UCP1 activity in BAT.

Mammal sirtuins are NAD + - dependent deacetylases that use NAD + as cofactor for catalyzed reactions to cleave acetyl groups from acetylated lysine residues of target proteins, generating nicotinamide (NAM) and 2 ′ - O - acetyl - ADP - ribose.

Not exact matches

Histone deacetylase inhibitors prevent p53 - dependent and p53 - independent Bax - mediated neuronal apoptosis through two distinct mechanisms.

Inactivation of the myocyte enhancer factor - 2 repressor histone deacetylase - 5 by endogenous ca2 / / calmodulin - dependent kinase ii promotes depolarization - mediated cerebellar granule neuron survival.

Histone Deacetylase 6 Is a FoxO Transcription Factor - dependent Effector in Skeletal Muscle Atrophy

Histone deacetylase inhibition modulates indoleamine 2,3 - dioxygenase - dependent DC functions and regulates experimental graft - versus - host disease in mice.