Sentences with phrase «dependent kinase»

In particular, the upregulation of the cyclin - dependent kinase inhibitor p21Cip1 / WAF1 upon LA exposure was found to be required for its anticancer properties.

Calcitriol induces G0 / G1 arrest, modulates p27Kipl and p21Waf1 / Cipl, the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest.

Both DAG and calcium are essential second messengers which activate downstream signaling components such as protein kinase C and calmodulin dependent kinase.

Au - Yeung G, Lang F, Azar WJ, Mitchell C, Jarman KE, Lackovic K, Aziz D, Cullinane C, Pearson RB, Mileshkin L, Rischin D, Karst AM, Drapkin R, Etemadmoghadam D, Bowtell DD.: Selective targeting of Cyclin E1 amplified high grade serous ovarian cancer by cyclin - dependent kinase 2 and AKT inhibition.

Rb and E2F remain bound together as a result of cyclin dependent kinase inhibition.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Senderowicz AM, Headlee D, Stinson SF, et al: Phase I trial of continuous infusion flavopiridol, a novel cyclin - dependent kinase inhibitor, in patients with refractory neoplasms.

The cyclin - dependent kinase (CDK) inhibitors p21waf1 and p27kip1 and underphosphorylated retinoblastoma protein levels were up - regulated and cyclin A levels were decreased in a concentration - dependent manner (Fig. 5B and C).

Additionally, we identified p21waf1 / cip1, a cyclin - dependent kinase inhibitor, as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression accounted for the colony - suppressing activity of DDX3.

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

Researchers from St. Jude Children's Research Hospital have discovered that inhibiting an enzyme called cyclin - dependent kinase 2 (CDK2) protects mice and rats from noise - or dr...

mammalian target of rapamycin (mTOR); cyclin dependent kinase inhibitor - 2A

Inactivation of the myocyte enhancer factor - 2 repressor histone deacetylase - 5 by endogenous ca2 / / calmodulin - dependent kinase ii promotes depolarization - mediated cerebellar granule neuron survival.

Glennie et al 134 have shown that T cells stimulated in co-cultures with MSC exhibit an extensive inhibition of cyclin D2 and upregulation of the cyclin dependent kinase inhibitor p27kip1.

Growth inhibition induced by antiprogestins RU - 38486, ORG - 31710, and CDB - 2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.

Cyclin - dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons.

Other gene abnormalities were, on the other hand, encountered in the other groups, such as c - Kit [19], cyclin - dependent kinase 4 (CDK4) and cyclin D1 (CCDN1)[20, 21].

Specifically, it inhibits cyclin - dependent kinase 4 (CDK4) and closely related CDK6; two factors that are essential to drive cells into DNA replication phase.

A randoMized phAse II trIal of fulvestraNt wiTh or without Ribociclib After progression on AntI-estrogeN therapy plus cyclin - dependent kinase 4/6 inhibition in patients with unresectable or metastatic hormone receptor positive, HER2 negative breast cancer (MAINTAIN Trial)

However, once opiate addiction had developed, the scientists observed a functional switch to a separate molecular memory pathway, controlled by a molecule called calmodulin - dependent kinase II or «CaMKII.»

A large number of hippocampal neurons were stained with cyclin - dependent kinase 5 in the offspring from the ethanol - treated group (immunofluorescence, x 400).

Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin - dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory.

THE STUDIES A trilogy of papers published in the September 28 issue of Nature examine the role of a protein — cyclin - dependent kinase inhibitor p16INK4a — in aging, healing, and cancer.

Prof. Ruiling Zhang and team from Xinxiang Medical University explored the correlation between cyclin - dependent kinase 5 expression in the hippocampus and neurological impairments following prenatal ethanol exposure, and found that prenatal ethanol exposure could affect cyclin - dependent kinase 5 and its activator p35 in the hippocampus of offspring rats.

In experiments on baker's yeast, Harbauer discovered that a cyclin - dependent kinase phosphorylates a mitochondrial protein at the beginning of mitosis, meaning that the kinase modifies the protein to activate it.

Or, in other words, the cyclin - dependent kinase complex is the orchestra, while the metabolic oscillations beat the rhythm, like a conductor does.

All textbooks describe the cyclin - dependent kinase complex as the one and only / exclusive regulator of the eukaryotic cell cycle.

The overall picture Heinemann and his colleagues have sketched in the Molecular Cell article is a system, in which the metabolic oscillator pulls the cyclin - dependent kinase complex through its cycle and dynamically gate the occurrence of the different cell cycle events.

«We argue that metabolism and the cyclin - dependent kinase complex are coupled oscillators, which together orchestrate the growth and division of eukaryotic cells.»

Dinaciclib is a member of a class of drugs known as cyclin - dependent kinase (CDK) inhibitors.

Researchers from St. Jude Children's Research Hospital have discovered that inhibiting an enzyme called cyclin - dependent kinase 2 (CDK2) protects mice and rats from noise - or drug - induced hearing loss.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

They found that CD44 + / CD24 - / Low cancer stem cells (CSCs) were resistant to conventional chemotherapy but were sensitive to SU9516, which is a specific cyclin - dependent kinase 2 (Cdk2) inhibitor.

(I keep waiting for the synthesis companies to make recommendations on their Web sites the way that Amazon and Netflix do: «If you liked the metalloprotease, you'll love this cyclin - dependent kinase!»)

Pfizer (pfe) breast cancer treatment Ibrance burst onto the scene in early 2015 and proceeded to dominate in a new therapeutic arena called cyclin - dependent kinase (CDK) 4 and 6 inhibitors.

To understand how this accumulation occurs in response to DNA damage, the scientists considered the role of CDK, or cyclin - dependent kinases.

Among the serine - threonine kinases, p38, Rho - kinase, cyclin - dependent kinases, and Chk1 have been targeted with productive results for inflammation and cancer.

Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin - dependent kinases in Saccharomyces cerevisiae.

An InCytes from MBC Selection: Regulation of Cell Polarity through Phosphorylation of Bni4 by Pho85 G1 Cyclin - dependent Kinases in Saccharomyces cerevisiae.

Centrosome amplification in CHO and DT40 cells by inactivation of cyclin - dependent kinases.

P16 binds to cyclin - dependent kinases 4 and 6 (CDK4 and CDK6) and inhibits phosphorylation of Rb, which remains associated with the transcription factor, E2F.

Cyclin - dependent kinases regulate splice - specific targeting of dynamin - related protein 1 to microtubules.

The cell cycle progression of eukaryotic cells is well controlled by cyclin, cyclin - dependent kinases (cdk), and cdk inhibitors.

His research projects focused on the host cyclin - dependent kinases and HIV - 1 reverse transcription, as well as the T cell intrinsic responses in various patient cohorts to HIV - 1 infections.

Cyclins form complexes with cyclin - dependent kinases (CDKs), unique to each cell - cycle phase, and activate specific genes to drive cells through their cycles.

Not exact matches

Cyclic adenosine monophosphate (cAMP)- dependent protein kinase, labeled with fluorescein and rhodamine on the catalytic and regulatory subunits, respectively, was injected into Aplysia sensory neurons either in culture or in intact cell clusters.

P significantly increased hypothalamic cAMP levels and cAMP - dependent protein kinase activity.

Cunningham and her postdoc at the time, Christine Kirvan, found that the antibodies literally bind to human neurons, activating an enzyme called calcium / calmodulin - dependent protein (CaM) kinase II.

When calcium floods a neuron as a memory is formed, it turns on an enzyme called CaMKII (calcium / calmodulin - dependent protein kinase).

The foraging gene encodes a cell signalling molecule called a cGMP dependent protein kinase.