Sentences with phrase «dependent mechanism of cancer»
Cancer exome analysis reveals a T - cell - dependent mechanism of cancer immunoediting Nature DOI: 10.1038 / nature10755
http://massgenomics.org/ Not exact matches
In this way our study took a very different approach as we have used chemistry to mimic genetic mechanisms that are able to block the development of Ras - dependent cancers.»
Published in the May 1 edition of Cancer Research, the study supports a critical role for IGF - 1R signaling in prostate - tumor development and identifies an important IGF - 1R - dependent growth control mechanism, according to the authors.
Mechanism of irradiation - induced mammary cancer metastasis: A role for SAP - dependent Mkl1 signaling.
Specifically, my research proposal addresses the mechanisms by which the kinase 3 - phosphoinoside dependent protein kinase - 1 (PDK1) mediates resistance to cell cycle related CDK4 / 6 inhibition in ER + breast cancer and explores the in vivo effects of inhibiting PDK1 in combination with CDK4 / 6 inhibitors toward ER + breast cancer growth.
Many mechanisms of MDR have been described, such as the overexpression of MDR1 (also known as P - glycoprotein or ABCB1) or other ATP - dependent transporters that pump drugs out of the cancer cells, amplification of drug - inactivating enzymes, mutations or modifications of drug targets, alterations in DNA repair machinery, and increased resistance to apoptosis (1 — 3).