Sentences with phrase «dependent on their genes»

A baby's height is dependent on their genes, but weight will help you to determine if they are absorbing nutrients properly when they eat.

Vettorazzi & Co. now found that the receptor's therapeutic impact is strictly dependent on the gene - activating function of the GR - dimer to suppress inflammatory processes.

Fertility is dependent on your genes, nutrition and lifestyle.

Not exact matches

Simply put, a phenotype is an observable set of properties that varies among individuals and is directly dependent on that individual's genes.

Epigeneticists have found that our cells carry a type of memory of the experiences of our ancestors — not only that, but 95 % of our genes aren't yet coded at birth, dependent on nurturing and the environment to determine their fate.

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

«Genes previously linked to schizophrenia seem to be dependent on the controlled release of dopamine at specific locations in the brain.

A study of 22 different types of lichens revealed 10 included fungi that had lost a gene for energy production, making them completely dependent on their algal partner.

The fungal partner in many lichen jettison a gene that's critical for energy production — making them completely dependent on their algal associates.

The AHR ligands turned on AHR - dependent genes and blocked the TGFβ - driven transformation of human orbital fibroblasts to scar - forming myofibroblasts.

«We provide the first evidence that the PPARα - dependent gene Fgf21 demethylation occurs in the postnatal mouse liver, and once established it persists into adulthood and exerts long - term effects on the magnitude of gene expression response to environmental cues, which may account in part for the attenuation of diet - induced obesity (Figure).»

According to the study, EWS / FLI binding and gene activation at promoter - like microsatellites is highly dependent on the length of GGAA motifs.

To ensure that an organism with a man - made genome could never survive outside the laboratory, the scientists inserted a gene to make it dependent on an antibiotic.

They are also hot on the trail of genes for inflammatory bowel disease, insulin - dependent diabetes and psoriasis, says Kári Stefansson, deCode's president.

The investigators also looked for other potential changes, such as hippocampal asymmetry or gene dose - dependent effects on volume, but could find no associations with genetic status.

Studying the expression of genes that are dependent on vitamin D makes it possible to identify individuals who will benefit from vitamin D supplementation, shows a University of Eastern Finland study published recently in PLoS One.

The results on temperature - dependent CIRBP gene expression are published in the journal Genes & Development.

Junji Hirota at Tokyo Tech and team focused on discovering a long - range enhancer for a large gene cluster, finding an evolutionary conserved sequence motif in mammalian evolution, and elucidating enhancer - dependent allelic preference or exclusion mechanism for odor - detecting receptor genes.

He received his doctoral degree in 1996 at the Ludwig Maximilians University in Munich for work on activity - dependent regulation of neurotrophin gene expression.

Other gene abnormalities were, on the other hand, encountered in the other groups, such as c - Kit [19], cyclin - dependent kinase 4 (CDK4) and cyclin D1 (CCDN1)[20, 21].

Benedikt received his doctoral degree in 1996 at the Ludwig Maximilians University, Munich for work on activity - dependent regulation of neurotrophin gene expression.

Among the study findings, IR mutations alter expression of many genes both in fibroblasts and iPSCs compared to normal cells, «but the impact is very much dependent on the cell type,» says Kahn.

For example, the BR biosynthesis gene, Dwarf4 (Dwf4), had opposite effects on yield in rice when driven by different promoters (Reuzeau et al., 2006; Wu et al., 2008) and the interaction of BR and GA mutants was developmentally context - dependent in maize (Best et al., 2016).

Furthermore we made the discovery that in a model of lung inflammation the anti-inflammatory action of glucocorticoids is not dependent on the inhibition of pro-inflammatory mediators, but rather requires cooperation with pro-inflammatory signaling pathways (e.g. p38) to induce anti-inflammatory acting genes and alternative polarization of macrophages.

Additionally, sex differences were recently also described in the transcriptome of human placental cells, demonstrating an influence of fetal sex on placental gene expression in a cell - type dependent manner (186).

Understanding how these effects are dependent on the post-mortem interval is essential for the proper use of post-mortem gene expression measures as a proxy for ante-mortem physiological gene expression levels5, 10,18,19,20.

The gene - targeting approach developed by Suzuki and his colleagues relies on the use of so - called helper - dependent adenoviral vector to deliver large mutation - free DNA molecules into cells.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Additional Caltech authors on the paper, «Cre - dependent selection yields AAV variants for widespread gene transfer to the adult brain,» are Sripriya Ravindra Kumar, Ken Y. Chan, Abhik Banerjee, Wei - Li Wu, and Bin Yang, as well as former Caltech students Piers L. Pravdo and Bryan P. Simpson.

The new type of nerve cell is dependent on DMRT3, and is tentatively named after this gene», tells Klas Kullander.

DNMT1 sites were found to be dependent on DAXX for recruitment by analyzing DNMT1 ChIP - Seq following DAXX knockdown (K / D), corroborating previous findings that DAXX recruits DNMT1 to repress its target genes.

The transcription factors usually function as homodimers or heterodimers to regulate the gene expression in eukaryotic cells and their activities are dependent on distinct protein - protein interaction.

On the other hand, IRF - 1 can also induce RIG - G gene expression through an IRF - 9 / STAT2 — dependent or IRF - 9 / STAT2 — independent mechanism.

A Harpin Binding Site in Tobacco Plasma Membranes Mediates Activation of the Pathogenesis - Related Gene HIN1 Independent of Extracellular Calcium but Dependent on Mitogen - Activated Protein Kinase Activity

The development of these structures depends on the terminal gap genes tll and hkb, whose expression at the posterior pole is solely dependent on Tor signaling.

Such a potential may also be dependent on the original cell type and may suggest retention of the gene expression memory of the donor cell in iPSCs.

Many of the DNMT1 peaks were lost after DAXX knockdown (2,237 DNMT1 peaks in WT (Figure 2C) vs. 600 DNMT1 peaks in DAXX K / D (Figure 2E)-RRB-, indicating that DNMT1 recruitment is almost entirely dependent on DAXX further corroborating previous findings that DAXX recruits DNMT1 to repress its target genes [2].

According to the findings it seems that regulation of gene activity is dependent on stuctural changes in the cell chromatine.

However, the evolution of advanced protein mutants with desired features is strongly dependent on efficiently targeting the gene of interest, the type of selective pressure chosen and the selection scheme allowing recovery of enhanced mutants.

The researchers also found that genes that have X and Y counterparts, or gene pairs, are more likely to be dosage - sensitive — dependent on expression by both chromosome pairs.

Such tissue - dependent expression often depends on which version of the gene an individual has inherited.

In this study, we show that the pathophysiological consequence of Themis1 deficiency depends on another gene that plays key roles in TCR - dependent signaling.

The body's genes are constantly communicating with the nutrients we take in through food; in fact, seventy - five percent of our health is dependent on what we have done to our genes throughout life, instead of what our family genes do to us.1 In other words, food either feeds or poisons a cell.

However, Resting Metabolic Rate accounts for approximately 65 - 70 % of your total daily calorie needs, but it is also dependent on age, physical activity, gender, environment temperature, genes, body composition (muscle to fat ratio), dieting, fasting.

We're almost in a post-genomic era because what we now know is we've got our DNA and genes but what's more important is the DNA and genes of the trillions of microbes that our body is dependent on.

How much amylase you have is highly dependent on how many salivary amylase genes you have.

To develop a better understanding of the preventative and therapeutic potentials of LA, much of the current interest is focused on elucidating its molecular mechanisms in redox dependent gene expression.

However, this dog's coat color is also dependent on the K, A, and B genes.

However, this dog's coat color is also dependent on its genotypes at the E and B genes.