Not exact matches
Osteocalcin's effects appear to be
dependent on the expression of RbAp48.
Although the metabolic responses observed are consistent with the cellular consequences of
osteocalcin exposure in pancreatic β - cells and myoblasts in vitro (27 — 29, 61), the metabolic effects of exercise and WBV may not be
dependent on
osteocalcin per se.
In the past few decades, scientists have realized that vitamin K2, menaquinone, is largely responsible for activating vitamin K -
dependent proteins (VKDPs), such as
osteocalcin and matrix Gla - protein.
MK - 7, on the other hand, activates another Vitamin K -
dependent protein called
osteocalcin.
However, in order to have these many effects in the body,
osteocalcin must be activated to its carboxylated form by vitamin K -
dependent proteins, known as matrix - GLA proteins, or MGPs.
In older, non diabetic men, three years of supplementation with 500 micrograms / day of vitamin K1 produced a significant reduction in insulin resistance compared with controls.43 And in a study of healthy young men, just four weeks of supplementation with 30 mg of K2 three times daily improved insulin sensitivity.44 This may have occurred as a result of an increase in the vitamin K -
dependent Gla - protein
osteocalcin, which has been shown in animal studies to increase insulin secretion and sensitivity.45