Analysis of the distance, latency, and cumulative search error (CSE) rank - summary scores revealed that MCI - AD patients and hAPP mice were significantly impaired in this task (Table 1 and Figure 1, B — D and F — I), consistent with a deficit in hippocampus -
dependent spatial learning.
In the AD reversal treatment strategy described here, J147 significantly improved several different aspects of memory affected in AD, including
spatial memory, a disinhibition phenotype and hippocampal
dependent associative
learning (Figure 1).