The inclusion
depletion of Glutathione, mitochondria increase lipid peroxidation and increase oxidative damage of proteins and DNA in the brain.
They talk about the most important mechanism by which Mercury causes toxicity appears to be Mitochondrial damage via
the depletion of Glutathione, coupled with binding to thiol groups, which generate free radicals.
It prevents
depletion of glutathione, and by that toxic accumulation in the liver that can lead to its permanent damage.
The depletion of glutathione is behind many skin - related effects you might have noticed from binge drinking; there's fewer antioxidants to defend cells, so they age faster.
Depletion of glutathione itself can be avoided very easily by providing the extra building blocks like magnesium and amino acids (see below).
Cellular
depletion of glutathione has been implicated as a causative, or contributory factor in many pathologies including Parkinson's, Alzheimer's, cataracts, arteriosclerosis, cystic fibrosis, malnutrition, aging, AIDS and cancer (Bounous et al., 1991).
Depletion of glutathione is essential to the mechanism of acetaminophen (Tylenol) toxicity, for example, which accounts for half of all cases of acute liver failure in the United States and Great Britain.
Here's how it works: Silymarin protects against
depletion of glutathione, a powerful antioxidant that helps fight oxidative stress, which can lead to skin, breast, prostate and cervical cancer, diabetes, and heart disease.
Not exact matches
There is no doubt that the
depletion of cellular
glutathione is one
of the salient characteristics
of CFS.
Research shows primary reason people develop TILT is
depletion of the master antioxidant:
glutathione.
When this pathway breaks down it causes increased levels
of oxidative stress within the cell that leads to the
glutathione depletion and mitochondrial dysfunction (17).
As for acne, I would estimate from all the studies I've reviewed that roughly half
of pesticides and herbicides cause either serious inflammation in the body or
depletion of important antioxidants such as
glutathione.
The catastrophic effects
of alcohol overdoses are largely down to
glutathione depletion from the liver.
Fluoride can damage the hippocampus and increase the uptake
of aluminium, which is linked to early onset Alzheimer's disease, as well as acne due to
glutathione depletion.
Therefore I strongly advice all acne patients to purchase organic grapes, or experience the consequences
of pesticides including chronic inflammation and
glutathione depletion.
Research shows a primary cause for the development
of TILT is the
depletion or poor absorption
of a particular antioxidant:
glutathione, also known as the «mother
of all antioxidants.»
Muscle cells ordinarily contain significant levels
of glutathione, and its
depletion leads to mitochondrial damage.23 Patients undergoing surgical trauma have been found to exhibit reduced
glutathione levels in their skeletal muscles.21 It is tempting to speculate that cholesterol sulfate provides the sulfur needed for
glutathione synthesis, so that the deficiency would be explained by the reduced availability
of cholesterol following the immune system's heightened response to surgical trauma.