An enzyme intended to clear
deposits of amyloid protein in the brain didn't help people with Alzheimer's disease
«The activity of the microglia is stimulated by dying brain cells, not by
the deposits of amyloid proteins, called plaques, which also occur in Alzheimer's disease,» Haass notes.
Not exact matches
Because PIB selectively binds to brain
amyloid deposits but quickly clears from normal tissue, the chemical dye accurately indicates the amount
of protein that is
deposited in the living brain.
Previously, researchers have focused on the role
of protein deposits called
amyloid plaques that lodge in the brain
of Alzheimer's affected people.
More than 40 illnesses known as
amyloid diseases — Alzheimer's, Parkinson's and rheumatoid arthritis are a few — are linked to the buildup
of proteins after they have transformed from their normally folded, biologically active forms to abnormally folded, grouped
deposits called fibrils or plaques.
Studies in mice specially bred to have features
of the disease found that DHA reduces beta -
amyloid plaques, abnormal
protein deposits in the brain that are a hallmark
of Alzheimer's, although a clinical trial
of DHA showed no impact on people with mild to moderate Alzheimer's disease.
In the new study, Ances and colleagues used one
of these tags and an
amyloid - binding one to analyze
deposits of both
proteins in 10 people with mild AD and 36 healthy adults.
The fibrils
of the body's own
amyloid beta (Aβ)
protein are the main constituent
of Alzheimer's disease related and characteristic pathological
protein deposits in the brain.
Immunotherapy is a promising strategy for the treatment
of Alzheimer's that uses antibodies to stimulate the immune system to remove pieces
of a
protein called
amyloid beta which accumulates in the brain (in
deposits known as plaques) and is thought to be a major factor driving Alzheimer's neurodegenerative effects.
Other researchers later showed that the brains
of men with CTE had a second type
of protein deposit called
amyloid, another hallmark
of Alzheimer's.
This study is important as it shows that a single night
of sleep deprivation can lead to an increase in
amyloid, a
protein associated with Alzheimer's disease,
deposited in the brain.
«This study reports
amyloid protein deposits in the blood vessels
of four people decades after receiving brain surgery.
Interestingly, most
of the people showing the
amyloid deposits in their brains did not also have the other hallmark sign
of Alzheimer's, the fibrous tangles
of the tau
protein.
The researchers were specifically looking at levels
of beta -
amyloid deposits in spaces between nerve cells as well as tangles, knotted threads
of the tau
protein inside brain cells.
Familial
amyloid polyneuropathy is characterized by abnormal
protein deposits that can affect the nerves and other functions
of the body.
The researchers were looking for two specific types
of protein:
deposits of beta -
amyloid plaque and knotted threads
of tau
protein tangles.
Scientists have identified a basic pathologic process underlying Alzheimer's development that involves the formation
of abnormal
protein deposits in the brain known as beta -
amyloid plaques, but they still aren't entirely sure what causes this to happen.
The other is amyloidosis, a condition in which
deposits of the
protein amyloid collect in canine organs and tissues.
Amyloidosis refers to a variety
of conditions in which
amyloid proteins are abnormally
deposited in organs and / or tissues.