Using cloning technology to
derive embryonic stem cells genetically identical to a patient is potentially very important, not only to provide a source of cells that may be used to cure patients, but also to allow for genetic disease to be studied and potential drug treatments to be explored in the laboratory.
At the so - called «blastocyst stage,» when the embryo might be destroyed to
derive embryonic stem cells, he or she is already a living, individuated organism.
JOE PALCA: Well, John, what they did was they - instead of starting with embryos and using those to
derive embryonic stem cells, they started with skin cells, or actually precursors to skin cells called fibroblast, that we all have in our skin.
The researchers in Oregon say they used those cloned monkey embryos to
derive embryonic stem cells.
The second method used somatic cell nuclear transfer (cloning techniques) to exchange all the mtDNA from the patient's cells with normal mtDNA from an egg donor in order to
derive embryonic stem cells that are patient - specific with respect to nuclear DNA, but «rescued» with respect to mtDNA.
This approach is now being used to
derive embryonic stem cells from a variety of strains including disease models from which in vitro tools are in demand, including mouse models of Alzheimer's disease, cytogenetic disorders (Turner's syndrome and Down syndrome), and tool strains for systems genetics.
In the past few months, researchers in the United States and Japan have described a promising way of
deriving embryonic stem cells from skin cells (of mice) without destroying embryos — the «Holy Grail of biotechnology,» as The Times of London put it.
The majority of gene - targeting experiments in mice are performed in 129Sv -
derived embryonic stem (ES) cell lines, which are generally considered to be more reliable at colonizing the germ line than ES cells derived from other strains.
The lab, called the MStem Cell Laboratories,
derived embryonic stem cells from the embryo, and coaxed them to grow into nerve cells.
Not exact matches
Two new papers have just been published documenting further advances with induced pluripotent
stem cells ---
stem cells that are «
embryonic - like» but that are not
derived from embryos.
On his website he writes: «
Embryonic stem (ES) cells are pluripotent
stem cells
derived from inner cell mass of mammalian blastocysts.
The researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA») for short, in human
embryonic kidney cells, brain cell samples and neurons
derived from the
stem cells of healthy people and those with spinal muscular atrophy type I and II.
He ruled that work on existing
embryonic stem cell lines
derived outside federally funded labs did not violate a ban on the destruction of embryos.
Some scientists had claimed that the lymphatic system was
derived from specialized
stem cells called angioblasts, whereas others had argued that it originated by the differentiation of pre-existing
embryonic veins.
That includes not only procedures in which
embryonic -
stem - cell lines are created, but also those that use previously
derived cell lines.
Researchers at Geron, meanwhile, had successfully
derived neurons from human
embryonic stem cells and were pursuing research that would eventually look to repair the damage caused by spinal - cord injuries, a possible use for
embryonic stem cells that was much touted at the time.
But the factor that may make the discovery very significant is that umbilical cord blood can be saved, stored and multiplied without any of the ethical dilemmas facing
embryonic stem cell use, which are
derived from human fetuses.
For example, animal studies have shown that neurons
derived in the lab from human
embryonic stem cells improve Parkinson's symptoms; however, any residual
stem cells associated with those neurons could form masses of unwanted cells.
Consequently, a fundamental argument against using
embryonic stem cells and therapeutic cloning can not be
derived from existing constitutional law and additional court decisions.
In addition, where cells
derived from
embryonic stem cells are great at proliferating — a potentially critical feature if one wants to grow sufficient numbers of cells for clinical use — ones from the iPS lines were much feebler.
Two weeks after the experimental myocardial infarctions, the Seattle researchers injected 1 billion heart muscle cells
derived from human
embryonic stem cells, called human
embryonic stem cell -
derived cardiomyocytes, into the infarcted muscle.
Freed expects transplants of neurons
derived from
embryonic stem cells to enter the clinical arena soon as well.
The results of the experiment appear in the April 30 advanced online edition of the journal Nature in a paper titled, «Human
embryonic -
stem cell
derived cardiomyocytes regenerate non-human primate hearts.»
The newly discovered human cells, named «cord - blood -
derived embryonic - like
stem cells» or CBEs, are not quite as primitive as
embryonic stem cells, which can give rise to any tissue type of the body.
The
stem cells,
derived from human umbilical cord - blood and coaxed into an
embryonic - like state, were grown without the conventional use of viruses, which can mutate genes and initiate cancers, according to the scientists.
A person with spinal injuries today went down in history as the first to receive a treatment
derived from human
embryonic stem cells (hESCs).
The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their
embryonic state, and
deriving stem cells from them.
In an advance touted as a way around current political logjams, scientists have said they can
derive human
embryonic stem (ES) cell lines without destroying an embryo.
In 1998, scientists figured out how to
derive human
embryonic stem cells (ESCs) for medical research, and the method kicked off an intense debate.
So far only two Japanese groups have been authorized to
derive human
embryonic stem cells; one group has actually done so.
In 2008 a group of medical researchers led by Robert Lanza at Advanced Cell Technology in Worcester, Massachusetts, reported another leap: They discovered a way to avoid destroying the embryo by
deriving an entire
stem cell line from a single
embryonic cell.
An
embryonic stem cell -
derived retinal cell therapy is an attractive option because they can be used to regrow the retina cells that are lost in both diseases.
It is at this stage, when the fertilized egg is smaller than the period at the end of this sentence, that researchers extract the inner part of the blastocyst, from which
embryonic stem cells are
derived.
The study, which followed four individuals for a year after they were treated with
embryonic stem cell -
derived retinal pigment epithelial cells for macular degeneration, observed no serious side effects (tumor growth or other unexpected effects) related to the therapy.
In June Italian scientists announced the first human
embryonic stem cells
derived from parthenotes — embryo - like structures formed when an egg starts to divide on its own, with no sperm involved.
But if homologous recombination could be worked out in human (
embryonic)
stem cells, then cardiomyocytes with mutations in ion channels could be
derived, as well as a large number of other very useful disease models of other tissues.
These
stem cells, which are similar to highly sought - after
embryonic stem cells but
derived from adult cells and then reprogrammed, could be turned into the cell types needed for research, including neurons and intestinal and fat cells.
Scientists were even more stunned in July 2002 when researchers led by
stem cell biologist Catherine Verfaillie at the University of Minnesota reported that bone marrow —
derived cells they had injected into young embryos contributed to all three
embryonic layers, just as
embryonic stem cells would do.
Pluripotent
stem cells include
embryonic stem cells, which are
derived from early embryos, and induced pluripotent
stem cells, which are made by reprogramming cells taken from adult tissues such as skin.
(Cardiomyocytes
derived from human
embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts Nature Biotechnology)
A patient's own bone marrow
stem cells can form bone and cartilaginous tissue, not the underlying vasculature and nerve compartments; and,
embryonic stem cell
derived bone may prompt an immune rejection.
In March, President Barack Obama lifted Bush's ban on using federal funds for research on human
embryonic stem cells
derived after August 2001.
«Basically it comes [down] to how many eggs you would need to
derive one
embryonic stem cell line.»
In February 2004 Hwang and his research group reported the first
embryonic stem cell line
derived from a cloned human embryo.
One is using cells
derived from human
embryonic stem cells to treat spinal cord injury (although funding problems have stopped the trial enrolling new patients) and another is testing a treatment for age - related macular degeneration.
Months to years after transplantation, retinal cells
derived from human
embryonic stem cells appear healthy — and may have unexpectedly helped vision in some recipients
IPSC's are
derived from the donated skin or blood cells of adults and, with the reactivation of four genes, are reprogrammed back to an
embryonic stem cell - like state.
Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells
derived from
embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms.
Attempting to find middle ground in the contentious debate over human
embryonic stem cells, President George W. Bush announced 9 August that the National Institutes of Health (NIH) will be allowed to fund work with
embryonic stem (ES) cell lines — but only those lines that have already been
derived.
Embryonic stem (ES) cells are
derived from early embryos and can in theory become any cell in the body.