Sentences with phrase «derived allele frequencies»

It follows from the last point above that the vast majority of common human genetic variation, i.e. SNPs with derived allele frequencies of at least 5 %, is neutral or nearly neutral with respect to fitness.

Not exact matches

We did not find significant differences or deviations in a consistent direction in the frequency of derived alleles in islands of divergence within O. c. cuniculus or in either subspecies when defining differentiation based on the proportion of fixed differences versus shared polymorphisms (Figure 3); however, intervals of high FST in O. c. algirus did show a significant skew towards high frequency derived alleles.

Indeed, several admixture scenarios [44], [45] and selection at linked sites are expected to generate an excess of high frequency derived alleles, but the observation that most islands of differentiation are not enriched for high frequency derived alleles suggests that selection at linked sites is likely to have a relatively small contribution overall to the occurrence of areas of high differentiation.

Moreover, the fact that the inferred skew towards high frequency derived alleles was only detected in one subspecies is mostly consistent with asymmetric migration.

By analyzing imputed data for a large number of human traits, we empirically derive a model that more accurately describes how heritability varies with minor allele frequency (MAF), linkage disequilibrium (LD) and genotype certainty.