Sentences with phrase «derived cells in tumor»

Not exact matches

One type of cell, the polymorphonuclear myeloid - derived suppressor cell (PMN - MDSC), was present exclusively in the induced tumors.

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

The stem - cell - derived bone tissue helped repair cranial bone defects in mice without developing tumors or causing infection.

Another challenge is producing stem - cell - derived tissues or organs that don't develop teratomas — tumors that contain a variety of tissues found in different organs — when transplanted.

They found out that TiY is capable of distinguishing TICs from non-TICs in various human lung cancer cell lines and patient - derived lung tumors.

In collaboration with the group of Valerian Kagan, Ph.D., D.Sc., at the University of Pittsburgh, Gabrilovich and colleagues analyzed in great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surfacIn collaboration with the group of Valerian Kagan, Ph.D., D.Sc., at the University of Pittsburgh, Gabrilovich and colleagues analyzed in great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surfacin great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surfacin the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surfacin the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surface.

CNIO's Bioinformatics Unit has been key in comparing 900 cell lines derived from up to 35 tumor types in order to identify unique aspects of melanoma.

«FDG PET shows tumor DNA levels in blood are linked to NSCLC aggressiveness: Insights derived from FDG PET could improve treatment selection for patients with advanced non-small cell lung cancer.»

«We wanted to utilize platelets» intrinsic tendencies to accumulate at wounds and to interact with circulating tumor cells, for targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from activated platelets in the surgical site, due to generation of small platelet - derived microparticles upon the platelet activation.

EZH2 inhibition delayed tumor onset in KDM6A - null cells and caused regression of KDM6A - null bladder tumors in both patient - derived and cell line xenograft models.

«This development has the potential to enable earlier detection of solid tumors through a simple blood draw by substantially improving our ability to detect very low quantities of circulating DNA derived from tumor cells,» says corresponding author Hunter Underhill, M.D., Ph.D., who initiated the research while in the lab of senior author Jay Shendure, M.D., Ph.D., a professor in genome sciences at the University of Washington.

«In mammalian cells we have only been able to study ALT in cells derived from ALT - dependent tumors,» says Karlseder, who also employs roundworm models to test ALT - dependent telomere constructioIn mammalian cells we have only been able to study ALT in cells derived from ALT - dependent tumors,» says Karlseder, who also employs roundworm models to test ALT - dependent telomere constructioin cells derived from ALT - dependent tumors,» says Karlseder, who also employs roundworm models to test ALT - dependent telomere construction.

A section of a tumor organoid grown from cells derived from a patient with high - grade serous ovarian cancer (left) and a mini-tumor treated with ReACp53, resulting in extensive cancer cell death.

Meng and Nel also collaborated with Dr. Timothy Donahue, chief of gastrointestinal and pancreatic surgery and a Jonsson Comprehensive Cancer Center member, to demonstrate that treatment with the iRGD peptide can enhance tumor cell killing for patient - derived pancreatic cancers, growing subcutaneously in a mouse model.

«The results were remarkable, with significant shrinkage in patient - derived tumors,» said Memarzadeh, who also is an associate professor of obstetrics and gynecology and the director of the G.O. Discovery Laboratory at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and associate professor.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damagIn addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damagin CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

Genomic data from the HeLa cell line are also being released with the final version of the paper as a result of discussions between leaders of the National Institutes of Health (NIH) and relatives of Henrietta Lacks, from whose cervical tumor the original HeLa cell line was derived prior to her death in 1951.

The cells, called myeloid - derived suppressor cells (MDSCs), are found abundantly in the microenvironment around tumors.

The National Institutes of Health today announced in Nature that it has reached an understanding with the family of the late Henrietta Lacks to allow biomedical researchers controlled access to the whole genome data of cells derived from her tumor, commonly known as HeLa cells.

At the annual meeting of the American Diabetes Society in Washington, D.C., researchers from the medical schools of Keio and Osaka universities reported that they had substituted a tumor - derived islet for Faustman's spleen cells.

Furthermore, only those fusion - derived IEC - 6 cell clones that had undergone the changes in cellular growth indicative of neoplastic transformation produced tumors in mice.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channeIn an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channein which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channein one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channein the adjacent channel.

Using cultured cells derived from human tumors of the breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other tumor types.

These inhibitors effectively targeted and blocked Msi expressing cells, resulting in halted tumor growth in animal models as well as in patient - derived cancer cells, which harbor more complex mutations and are uniformly drug - resistant.

«Preclinical results support entinostat's role in targeting the tumor microenvironment: Entinostat inhibits function of myeloid derived suppressor cells resulting in enhanced antitumor effect in murine models of lung and renal cell carcinoma.»

One idea the team is mulling is to implant in patients a bag of iPS - derived liver cells that are self - contained, so they can't seed tumors in a patient's tissues but can still produce A1ATD.

«Inhibition of the EZH2 pathway slows growth of tumors in mouse brain derived from glioma stem cells from the enhancing margin of human tumors.

Such targets have recently been discovered in cell lines derived from aggressive childhood tumors using phenotypic profiling and RNAi screening.

Four months after receiving the treatment, the patients have not developed any tumors or abnormal growths that have sometimes been seen in animals receiving hESC - derived cells, the team reports online today in The Lancet.

Past clinical trials of stem cell therapies for chronic stroke patients used cells derived from tumors in humans and brain tissue from fetal pigs.

Kim, Jung - Sik, et al. «Intact cohesion, anaphase, and chromosome segregation in human cells harboring tumor - derived mutations in STAG2.»

However, efforts to examine the in vitro behavior of tumor cells with endothelial cells from different anatomical regions have been prohibited because, in large part, of the limited number of organ - derived endothelial cell lines available for study.

Lloyd A. Greene and Arthur S. Tischler of the Harvard Medical School demonstrated in 1977 that cells of the line designated PC12 (which are derived from a rat tumor) respond to NGF by acquiring properties characteristic of sympathetic neurons.

They found that injecting patient - derived, brain - seeking melanoma cells into the carotid artery of these preclinical models resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced melanoma cancer patients.

Research Interests: Tumor immunity, T lymphocyte effectors, immunotherapy, T - cell dysfunction in cancer, myeloid derived suppressor cells (MDSC) and angiogenesis

It is in this final tank that the engineered cells are stimulated to secrete the protein product — the monoclonal antibody itself, a protein derived from the mammalian immune system that can bind to a very specific target in the body, such as a tumor cell.

The researchers then injected AAV2 into human breast cancer cell line - derived tumors in mice without functioning immune systems.

The KPC1242 cell line, derived from a spontaneous pancreatic tumor that arose in a KPC mouse, was a generous gift of David Tuveson (Cold Spring Harbor Laboratories, Cold Spring, NY).

Further, consistent with T cell phenotypes in nontumor - bearing mice (Fig. 2), we observed an increased percentage of spleen - derived CD8 + T cells expressing high levels of the activation marker CD44 in DGKζ − / − or DKO mice that had been inoculated with tumor when compared with Cbl - b − / − or WT mice (Fig. 4C).

Currently, her research interest is focused on the functional characterization of cell - autonomous molecular determinants, known to control cardinal stem cell properties in normal NSCs, in the attempt of understanding their putative role in regulating the same properties in brain tumor - derived cancer stem cells.

In this fashion, they derive a signal from the tumor cells proportional to tumor mass which arises spontaneously in vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLCIn this fashion, they derive a signal from the tumor cells proportional to tumor mass which arises spontaneously in vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLCin vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLCin the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLCin human non-small cell lung cancer (NSCLC).

Finally, I have a category of «other cancers» with exomes published in 2011; these include pancreastic cysts and cell lines, gastric cancer tumors, and prostate cancer samples derived through mouse xenograft models.

Excitingly, a single dose of any of the three NK cell populations assessed led to a significant reduction in tumor burden, although the iPSC ‐ derived NK group demonstrating a trend toward overall better activity.

In the new study, the research team screened 16 DIPG cell lines derived from patients» tumors against 83 possible chemotherapy drugs, exposing cells to small samples of each drug.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

Embryonic stem cells derived from human blastocysts have the key advantage of pluripotency, meaning that they form nearly all cell types but also have the disadvantage of forming tumors in vivo, which may limit clinical application to tissue engineering rather than cell transplantation.

When tertiary tumor transplantation experiments were carried out with P3C4 and P1E2 secondary tumor — derived cells, 1,000 cells again reinitiated tumor development in 90 % of injections (Table 1; Fig. 3C).

Importantly, when the three holoclone - derived tumors were harvested and PC3 - GFP cells were purified and used in secondary tumor transplantation experiments, 1,000 cells of each clone regenerated tumors in 70 % to 100 % of the injections (Table 1; Fig. 3B).

His lab has made contributions in the area of tumor induced immunosuppression of dendritic cells, characterization of human myeloid derived suppressor cells, and the development of novel adjuvants for cancer vaccines.

On the contrary, recent evidence indicates that XMRV is a contaminant originating from the recombination of two mouse endogenous retroviruses during passaging of a prostate tumor xenograft (CWR22) in mice, generating laboratory - derived cell lines that are XMRV - infected.