Sentences with phrase «derived models of disease»

His uses genome engineering methods to test the role of specific genetic changes in induced pluripotent cell (iPSC)- derived models of disease.

Not exact matches

«The ongoing line of work with this drug is an excellent example of the bench getting even closer to the bedside — our lab work with the drug in patient - derived xenograft models of disease makes possible the clinical trials taking place at the University of Colorado Hospital next door,» Jimeno says.

Dr Leonardo Guasti added: «It represents an entirely new concept for the study of the adrenal gland as the ability to generate donor - specific and functional adrenal - like cells will facilitate the next generation of cell - based treatments for adrenal insufficiency, the modelling of adrenal specific diseases, and the testing of personalised interventions on cells derived from patients.»

In this latest research, Mohan and his colleagues present new findings that detail the use of a synthetic, plant - derived compound — abbreviated CDDO — that was shown to effectively suppress the multiple steps of lupus development in murine models, including the onset of kidney disease.

«This work in an experimental model is the first published report of exploiting an uropathogen - derived host modulatory molecule in a clinically relevant model of bladder disease, and it points to the potential utility of this as an alternate treatment approach.»

But if homologous recombination could be worked out in human (embryonic) stem cells, then cardiomyocytes with mutations in ion channels could be derived, as well as a large number of other very useful disease models of other tissues.

He is also developing a robust and comprehensive panel of 3 - D cell culture models from patient - derived primary cells that can be used to characterize different disease phenotypes and investigate the chemo - response of cells to novel or known drugs.

Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»

Metabolites derived from the microbiome block protein misfolding in test tubes and prevent neurodegeneration in a fly model of a disease related to Parkinson's, hinting that gut - derived metabolites may hold therapeutic promise (Lap Ho, abstract 573.23, see attached summary).

This Purkinje neuron was derived from patients with tuberous sclerosis and model properties of the disease at the cellular and molecular level.

Our conversion process should model late - onset aspects of the disease using neurons derived from patients with the condition.»

«Lab - grown human colons change study of GI disease: Stem cell derived organoids fill gap in modeling common ailments.»

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

Susceptibility loci to coronary arteritis in animal model of Kawasaki disease induced with Candida albicans - derived substances

However, despite its marked promise for disease modeling, development of novel therapies, and regenerative medicine, stem cell derived organoid technology faces many remaining challenges.

Here, Anna presents how studies of neural stem cells and neurons derived from iPS cells of patients show faithful mimicking of known disease phenotypes in our cellular models of disease, like Alzheimer's disease, autism, and Down syndrome.

For these purpose, we explore and validate the use of cell progenies derived from pluripotent stem cells to produce disease models in a dish, to screen for compounds (small molecules, biologicals, etc).

In parallel to this cell therapy application, keratynocytes and melanocytes derived from pluripotent stem cells will be used for pathological modelling of genodermatoses allowing identification of new disease - specific pharmacological treatments

This approach is now being used to derive embryonic stem cells from a variety of strains including disease models from which in vitro tools are in demand, including mouse models of Alzheimer's disease, cytogenetic disorders (Turner's syndrome and Down syndrome), and tool strains for systems genetics.

Disease - specific human pluripotent stem cells, from embryonic origin or derived from reprogramming somatic cells, offer the unique opportunity to have access to a large spectrum of disease - specific cell Disease - specific human pluripotent stem cells, from embryonic origin or derived from reprogramming somatic cells, offer the unique opportunity to have access to a large spectrum of disease - specific cell disease - specific cell models.

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease

The experiments, performed in rat models of Parkinson's disease, reveal that the latest version of stem cell - derived dopamine cells fully mimic the characteristics and function of the dopamine neurons that are lost in Parkinson's disease.

He has developed novel cellular models of neurological diseases (schizophrenia, MS, autism, Alzheimer's, Parkinson's) using human induced pluripotent stem cells (iPSCs) derived from donor patients and differentiated to specific neuronal cell types.

This discovery, which earned Dr. Yamanaka the 2012 Nobel Prize in Physiology or Medicine, has revolutionized the fields of stem cell biology and regenerative medicine and has allowed scientists to model disease from patient - derived cells in a dish, thus working towards a new era of personalized medicine.

Reprogramming human somatic cells to pluripotency represents a valuable resource for the development of in vitro based models for human disease and holds tremendous potential for deriving patient - specific pluripotent stem cells.

In sum, human NSCs represent an invaluable source of cells to investigate human iPS induction, and also represent a potential source of cells for deriving patient - specific pluripotent stem cells for modeling human disease.

A recent article in Chemical & Engineering News describes the promising properties of curcumin, a compound derived from turmeric, in models of Alzheimerâ $ ™ s disease.

«The development of a functional human kidney glomerulus chip opens up an entirely new experimental path to investigate kidney biology, carry out highly personalized modeling of kidney diseases and drug toxicities, and the stem cell - derived kidney podocytes we developed could even offer a new injectable cell therapy approach for regenerative medicine in patients with life - threatening glomerulopathies in the future,» said Ingber.

Our lab uses both cardiomyoctes derived from human stem cells (iPS cell - derived cardiomyocytes) and mouse models harboring the human mutation to study which exact changes occur during the onset and development of the disease.

Taken together, these results demonstrated that disease - specific human iPS cell — derived hepatocytes are capable of modeling key pathological feature of A1ATD in vitro and may also prove useful for future drug screening assays.

Treatment of perianal fistulas with human embryonic stem cell - derived mesenchymal cells: a canine model of human fistualizing Crohn's disease.