Sentences with phrase «derived tumors in mice»

The researchers then injected AAV2 into human breast cancer cell line - derived tumors in mice without functioning immune systems.

Not exact matches

«We also confirmed a role in PDAC tumor maintenance as inhibition of PRMT1 in patient - derived mouse models significantly inhibited tumor growth and extended survival,» said Giuliani.

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

The stem - cell - derived bone tissue helped repair cranial bone defects in mice without developing tumors or causing infection.

In experiments with mice, the UC San Diego - led team showed that verteporfin also suppresses the growth of uveal melanoma tumors derived from human tumors.

In collaboration with the group of Valerian Kagan, Ph.D., D.Sc., at the University of Pittsburgh, Gabrilovich and colleagues analyzed in great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surfacIn collaboration with the group of Valerian Kagan, Ph.D., D.Sc., at the University of Pittsburgh, Gabrilovich and colleagues analyzed in great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surfacin great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surfacin the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surfacin the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surface.

«The use of a mouse tumor - derived matrix would limit any future applications of these organoid technologies in humans, and this work opens the door to research directed specifically for clinical applications,» noted Asma Nusrat, study co-author and the Aldred Scott Warthin Professor and Director of Experimental Pathology in the University of Michigan's School of Medicine.

Meng and Nel also collaborated with Dr. Timothy Donahue, chief of gastrointestinal and pancreatic surgery and a Jonsson Comprehensive Cancer Center member, to demonstrate that treatment with the iRGD peptide can enhance tumor cell killing for patient - derived pancreatic cancers, growing subcutaneously in a mouse model.

Furthermore, only those fusion - derived IEC - 6 cell clones that had undergone the changes in cellular growth indicative of neoplastic transformation produced tumors in mice.

«Inhibition of the EZH2 pathway slows growth of tumors in mouse brain derived from glioma stem cells from the enhancing margin of human tumors.

However, their initial finding demonstrated that progenitor derived from iPSCs generated using lentiviral gene transduction led to the high incidence of highly aggressive tumors in immunodeficient mice after transplantation under the kidney capsule.

Yasuaki Tamura, working with colleagues in the laboratory of Pramod Srivastava, demonstrates that tumor - derived heat shock protein - peptide vaccines can be used to treat a wide array of pre-existing tumors in mice.

These days, mice grafted with human tumors, known as patient - derived xenograft (PDX) mice, are common in cancer research laboratories.

To evaluate tumor growth in mice of each genotype, we used an orthotopic implant model derived from a spontaneous pancreatic tumor arising in a C57BL / 6 KPC mouse (33), which expresses mutant forms of K - Ras and p53 selectively in pancreatic tissue.

The KPC1242 cell line, derived from a spontaneous pancreatic tumor that arose in a KPC mouse, was a generous gift of David Tuveson (Cold Spring Harbor Laboratories, Cold Spring, NY).

Further, consistent with T cell phenotypes in nontumor - bearing mice (Fig. 2), we observed an increased percentage of spleen - derived CD8 + T cells expressing high levels of the activation marker CD44 in DGKζ − / − or DKO mice that had been inoculated with tumor when compared with Cbl - b − / − or WT mice (Fig. 4C).

Finally, I have a category of «other cancers» with exomes published in 2011; these include pancreastic cysts and cell lines, gastric cancer tumors, and prostate cancer samples derived through mouse xenograft models.

On the contrary, recent evidence indicates that XMRV is a contaminant originating from the recombination of two mouse endogenous retroviruses during passaging of a prostate tumor xenograft (CWR22) in mice, generating laboratory - derived cell lines that are XMRV - infected.