But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been
described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.
As Bialy
describes it, everybody cared about cancer, but the only man who understood that it was not caused by
oncogenes was scorned by his peers for changing his mind.