Sentences with phrase «design factors including»

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Note: Yelp's search results are based on an algorithm that is designed to provide the best results based on a number of different factors including review text, ratings, and number of reviews.

The parties blame that delay on factors including design changes requested by SBB to address complaints from associations for the disabled, as well as technical requirements related to the unique Gotthard Tunnel that required the car bodies to be redesigned.

«The thorough evaluation process [to earn the approval] included a detailed review of the design, critical factors and sterile zone boundaries of the machine,» explains Stephane Hacpille, vice president of sales for North America.

The obvious factors include the mobility and design.

The team found that other factors, including the distribution of mass in the front frame, play a role in keeping bicycles upright, an insight that could open up new design possibilities for bike manufacturers.

Factors at play include the specific path of a fish, the amount of water going through a turbine, the design of the turbine, the depth of water where the fish usually lives, and the physiology of the fish itself.

The survey, comprising of 146 male participants, asked questions designed to assess several considerations including the participants» perceptions of pregnancy, the benefits of Vasalgel, interpersonal factors, and social norms.

They then used an algorithm to optimize the design for various factors, including minimizing the number of relocations and maximizing the proportion of the lot that was used for parking versus lanes for relocation, entering or exiting.

«To understand the factors behind T - cell - receptor binding to peptides will have major impact on biomedical developments, including vaccine design and immunotherapy.»

Computer simulation experiments will be designed to investigate the effects of key factors on RS efficiencies such as heritability, crossing schemes including male - sterility - facilitated and manual crossing, selection intensity, etc..

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

Furthermore, we discuss key experimental design considerations, including the choice of the method used to determine metastatic burden and statistical analysis of the results, as well as provide troubleshooting tips and identification of factors that contribute to experimental variability.

Included with the program are the Venus Factor workout videos designed to complement the 12 week program.

It includes 12 key nutritional factors, including high doses of the B vitamins and my top 3 adaptogenic herbs in a unique, synergistic blend designed to boost energy and adrenal health safely and naturally.

This is an evaluation of factors including game design, level of immersion, and originality.

Increased detail in all players has been transferred to the Player Design mode, which has been hugely expanded to include more factors determining skill and ability.

This download includes Personal Learning Checklists for GCSE Engineering (AQA Specification) and covers the topics of «Material costs and supply» and «Factors influencing design of solutions».

This download includes 6 Personal Learning Checklists for GCSE Engineering (AQA Specification) and covers the topics of: Materials And Their Properties Material Costs And Supply Factors Influencing Design Of Solutions Engineering Manufacturing Processes Systems Testing And Investigation Practical Engineering Skills.

This means practicalities of construction — including material consideration, logistics and design constraints — can be factored into a project at a far earlier stage, reducing downtime, cost and allowing for better project planning.

Included is Number (standard form, sequences, ratio, prime factors, percentages) Algebra (factorising, graphs, indices, simplyifying and rearranging, solving) Geometry (angles in shapes, z angles, area, perimeter and volume, area and circumference of circles) Statistics, measurement and probability (box plots, probability, stem and leaf, questionnaire designing) Not all topics are included and this was designed for the EDEXCEL spec, but will be useful for otherIncluded is Number (standard form, sequences, ratio, prime factors, percentages) Algebra (factorising, graphs, indices, simplyifying and rearranging, solving) Geometry (angles in shapes, z angles, area, perimeter and volume, area and circumference of circles) Statistics, measurement and probability (box plots, probability, stem and leaf, questionnaire designing) Not all topics are included and this was designed for the EDEXCEL spec, but will be useful for otherincluded and this was designed for the EDEXCEL spec, but will be useful for other boards.

Barriers include cost, technology issues still not resolved, confusion about the differences between formal and informal learning, design factors, cultural factors, concerns about security, etc..

The board also includes a 1L UV dispenser filled with Deb's factor 30 sun cream, and has been designed to be engaging and attractive for primary school children.

All factors are evaluated in the context of the purpose, content, and organization of the piece, including consistency between design, purpose, and effectiveness of marketing message.

Among some of the factors that need to be addressed include the poorly - designed accountability system that is pushing schools into reconstitution, the mania for smaller schools, and whether to close low - performing schools altogether, Elmore said.

«It is crucial for a school rating system to take into account certain factors including appropriate leadership, staffing that meets the needs of students, resources to support teachers in designing and carrying out high quality plans, and facilities that provide a safe and comfortable environment to teach and learn.»

Courses will examine first and second language development; second language literacy development, assessment, and instruction; successful approaches to assessing and teaching oral language and content skills including designs for differentiating instruction according to students» levels of language proficiency; and the multiple factors that influence academic achievement among this student population.

States will now have the responsibility of designing an accountability framework incorporating and giving the most weight to academic factors, including student performance on state assessments and high school graduation rates, in addition to state - chosen indicators of school quality or student success, which can include measures of educator engagement and school climate / safety.

Interdistrict magnet schools are designed to attract students from all around the area and from all walks of life, but there are many factors that could affect which students end up applying to and attending the school, including both the school's marketing strategies as well as qualities of the school.

Several factors influence decisions about learning designs, including the goals of the learning, characteristics of the learners, their comfort with the learning process and one another, their familiarity with the content, the magnitude of the expected change, educators» work environment, and resources available to support learning.

A number of factors affect the quality of in - school modeling, including lack of resources available in field placements, lack of experience or expertise with regard to technology integration among field placement teachers, and lack of opportunities for preservice teachers to integrate technology in meaningful ways into the activities they design and implement during their field placements (Niess, 2008; Posner, 1996; Smoot, 2000).

The Online Texas Adolescent Literacy Academies (TALA) prepare middle school teachers to design appropriate instruction for all students, including those who struggle with reading due to limited English proficiency, learning disabilities, dyslexia, and other risk factors for reading difficulties.

Moreover, in Standard C. 2.2 Plan for Effective Instruction, it states, «Well - prepared beginning teachers of mathematics attend to a multitude of factors to design mathematical learning opportunities for students, including content, students» learning needs, students» strengths, task selection, and the results of formative and summative assessments» (p. 14).

Ten urban districts in California — including the Los Angeles Unified School District, the nation's second largest — collectively called CORE (California Office to Reform Education) districts, have designed a system to make schools answerable for improving students» social and emotional skills by using data from student, parent, and teacher surveys, among other factors, to assess whether students are improving in these areas.

(1997) E652: Current Research in Post-School Transition Planning (2003) E586: Curriculum Access and Universal Design for Learning (1999) E626: Developing Social Competence for All Students (2002) E650: Diagnosing Communication Disorders in Culturally and Linguistically Diverse Students (2003) E608: Five Homework Strategies for Teaching Students with Disabilities (2001) E654: Five Strategies to Limit the Burdens of Paperwork (2003) E571: Functional Behavior Assessment and Behavior Intervention Plans (1998) E628: Helping Students with Disabilities Participate in Standards - Based Mathematics Curriculum (2002) E625: Helping Students with Disabilities Succeed in State and District Writing Assessments (2002) E597: Improving Post-School Outcomes for Students with Emotional and Behavioral Disorders (2000) E564: Including Students with Disabilities in Large - Scale Testing: Emerging Practices (1998) E568: Integrating Assistive Technology Into the Standard Curriculum (1998) E577: Learning Strategies (1999) E587: Paraeducators: Factors That Influence Their Performance, Development, and Supervision (1999) E735: Planning Accessible Conferences and Meetings (1994) E593: Planning Student - Directed Transitions to Adult Life (2000) E580: Positive Behavior Support and Functional Assessment (1999) E633: Promoting the Self - Determination of Students with Severe Disabilities (2002) E609: Public Charter Schools and Students with Disabilities (2001) E616: Research on Full - Service Schools and Students with Disabilities (2001) E563: School - Wide Behavioral Management Systems (1998) E632: Self - Determination and the Education of Students with Disabilities (2002) E585: Special Education in Alternative Education Programs (1999) E599: Strategic Processing of Text: Improving Reading Comprehension for Students with Learning Disabilities (2000) E638: Strategy Instruction (2002) E579: Student Groupings for Reading Instruction (1999) E621: Students with Disabilities in Correctional Facilities (2001) E627: Substance Abuse Prevention and Intervention for Students with Disabilities: A Call to Educators (2002) E642: Supporting Paraeducators: A Summary of Current Practices (2003) E647: Teaching Decision Making to Students with Learning Disabilities by Promoting Self - Determination (2003) E590: Teaching Expressive Writing To Students with Learning Disabilities (1999) E605: The Individualized Family Service Plan (IFSP)(2000) E592: The Link Between Functional Behavioral Assessments (FBAs) and Behavioral Intervention Plans (BIPs)(2000) E641: Universally Designed Instruction (2003) E639: Using Scaffolded Instruction to Optimize Learning (2002) E572: Violence and Aggression in Children and Youth (1998) E635: What Does a Principal Need to Know About Inclusion?

Michael Turner, director of the JCQ, said: «There are many underlying factors affecting this year's GCSEs, including a sizeable increase in entry by 15 - year - olds, new science specifications designed with greater challenge, early and multiple entry in mathematics and an increase in the number of students taking IGCSEs [international GCSEs].

Factors influencing the design choice include cost, complexity, reliability, packaging (location and size of the passenger compartment and boot), weight distribution, and the vehicle's intended handling characteristics.

Editors graded each of the 10 finalists on various criteria, including drivetrain, ride quality, handling, exterior, interior design and «fun factor.»

The design provides direct control of the wheels; there is no differential mechanism as in some other electric vehicle designs — a key point, Pint emphasized, for a number of factors including weight, response, and span of control.

Pricing will depend on a variety of factors including your timescale, and the number of design rounds you require.

Those factors included the availability of technology that would allow the construction of a tablet that was thin enough, light enough, would have enough battery life and be designed well enough to meet the broad acceptance it needed.

Whether or not a book needs a facelift depends on a number of factors, including (most importantly) hardcover sales, the hardcover design's commercial accessibility, and its reproducibility in paperback.

Some strategic beta indices focus on a single factor; these indices are designed to include only those stocks that score well based on a particular factor.

Key portfolio characteristics include a «through retirement» glide path designed to account for an investor's full life expectancy, a managed volatility approach, as well as portfolios combining active strategies plus factor - based and market - cap - weighted exchange - traded funds (ETFs).

Basic and Transition Field Manuals Mitch White - [email protected] Basic and Transition Training and Designing Retriever Training Set - Ups manuals: the basic manual covers puppy selection through honor / steadiness and includes a section on test setups and tests; the transition manual focuses on a clear understanding of transition and advanced training, including drills for teaching advanced concepts; the designing set - ups manual focuses on bird placement and training on factors.

1 Key factors to consider when designing your horse's vaccination program with your veterinarian include:

This is an evaluation of factors including game design, level of immersion, and originality.

Human psychology is, unfortunately, a factor they are forgetting to include in their designs.

As I explained above — major dams are designed by a different method of estimating probable maximum precipitation from recorded high intensity storm precipitation transformed by local and regional factors including moisture availability.