Sentences with phrase «design immunogens»
«Then the ultimate proof of utility of this discovery is to use it to design immunogens that can induce broadly neutralizing antibodies by vaccination.»
https://www.sciencedaily.com/ Not exact matches
Using the findings from this study, the team has designed vaccine immunogens to selectively trigger the cooperating antibody - producing B cells to cooperate to make broadly neutralizing antibodies in a manner that mimics broadly neutralizing antibody development in natural HIV infection.
Immunogens are designed to elicit the production of highly coveted broadly neutralizing antibodies that protect against HIV - 1 [Also see Report by McGuire et al..]
A critical implication of this work for the field of HIV vaccine design is the observation that the most potent and broad individual anti-HIV VHH, J3, was elicited in response to the gp140 immunogens used.
For the published request for applications, see the May 18, 2016 Guide announcement, Partnerships for Structure - Based Design of Novel Immunogens for Vaccine Development (R01).
Dr. Schief's work focuses on computation - guided and structure - based design of immunogens and immunization regimens, with the goal of inducing broadly neutralizing antibodies against HIV and other pathogens that have frustrated traditional vaccine design strategies.
Researchers are making progress in developing vaccine immunogens designed to induce broadly neutralizing antibodies (bNAbs) against HIV.