Sentences with phrase «design small molecule drugs»
«We could apply the strategy used in this study to quickly identify and design small molecule drugs for other RNA - associated diseases,» explained study first author Sai Velagapudi, a research associate in the Disney lab.
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In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.
Small molecule drugs can be screened or designed to increase telomerase activity exclusively within stem cells for disease treatment as well as anti-aging therapies without increasing the risk of cancer.
«They also provide a promising strategy for identifying small molecule drugs designed to treat Alzheimer's disease and other neurological disorders.»
Anderson and Valerie Grum - Tokars, a junior structural biologist on the team, developed a three - dimensional structure of human p38 MAPK, enabling the chemists to design and synthesize novel drug - like small molecules that would disable it.
An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.
The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.
Other companies, including the Swiss drug giants Novartis and Roche, along with Boston's Paratek Pharmaceuticals, are developing ingestible small - molecule drugs designed to increase the inclusion of SMN2 «s exon 7.
Further the Meiler laboratory develops a structure - based drug design module for ROSETTA and docking protocols particularly suited for docking small molecules into comparative models.
As reported online in PLoS One on October 3, Hopkins colorectal cancer specialists John Abraham, Ph.D., and Stephen Meltzer, M.D. - working with the notion that small molecules generally make better treatment packages - designed small bits of protein only 10 amino acids long as the foundation for their drugs.
I am interested in Scientist position for designing and developing novel small molecules, developing new synthetic routes and process optimization, for drug discovery and development.