Sentences with phrase «design small molecules»

However, it's not easy to design small molecules against transcription factors

Knowing the structures of pathological forms of amyloid seeds should help to design small molecules that bind to them and stop them doing damage, says biophysicist Ronald Melki at the Paris - Saclay Institute of Neuroscience, who works on α - synuclein strains.

«We could apply the strategy used in this study to quickly identify and design small molecule drugs for other RNA - associated diseases,» explained study first author Sai Velagapudi, a research associate in the Disney lab.

Hakonarson hopes that his team's discovery will lead to better therapies by designing small molecules to bind this receptor — thereby reducing the destructive inflammation.

«The challenge now is to see if we can design a small molecule to do the job,» says Andrea Gamarnik at the Leloir Institute in Buenos Aires, Argentina.

«If we could design a small molecule inhibitor that would look like heme - iron but would actually clog up a key metabolic pathway in bacteria, we may be able to get around the problem of antibiotic resistance,» suggests Dr. Mason, who adds that he and Dr. Justice plan to use the new five - year NIH grant to further studies of just such an inhibitor.

Today in PLOS Pathogens, scientists report that they've designed small molecules to target a particularly vulnerable region of hemagglutinin, one of the two proteins that jut from the viral surface like a flower.

His research focuses on the long - term goal of designing small molecule therapeutics for prion diseases — fatal neurodegenerative diseases caused by the spread of misfolded proteins across the brain.

He went on to a postdoctoral position with Dr. Iwao Ojima evaluating anti-tubercular compound series that inhibit the cell division protein FtsZ and screening computationally designed small molecule inhibitors of Botulinum neurotoxin.

Not exact matches

These processes, however, are designed to remove larger organic molecules with lower solubility, thus removal of very small molecules with high solubility is difficult.

Already, large companies such as DuPont are harnessing synthetic biology, and small companies «are being built around the idea of using organisms, designing organisms, using tools of synthetic biology to make molecules that can't be produced any other way,» Glass says.

David Cullen, a biotechnologist from Cranfield University in England, recently tested sensors designed to identify microbes embedded in the ice by searching for cell - wall molecules and small snippets of DNA.

The researchers designed and synthesized a novel small molecule PET tracer, 18F - MPG, with high specificity to activating EGFR mutant kinase.

The new - generation microporous material designed at Dartmouth is the result of chemically stitching small organic molecules to form a framework that scrubs the isotope from water.

Visualizing this molecular structure creates a platform for designing new, more effective small molecule therapeutics to treat depression and anxiety.

The design inspiration for the new particles came from the natural world — specifically, small particles known as lipoproteins, which transport cholesterol and other fatty molecules throughout the body.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

Small shining molecules developed by scientists at Linköping University in Sweden can be designed to distinguish between plaque of different proteins in the brain.

«We were making small, easily synthesized, programmable molecules» — molecules designed and synthesized with parts that control their behavior — «which assembled on the nanoscale into highly functional materials,» Smith says.

Small molecule drugs can be screened or designed to increase telomerase activity exclusively within stem cells for disease treatment as well as anti-aging therapies without increasing the risk of cancer.

«They also provide a promising strategy for identifying small molecule drugs designed to treat Alzheimer's disease and other neurological disorders.»

In addition to Disney and Velagapudi, authors of the study, «Design of a Small Molecule Against an Oncogenic Non-coding RNA,» were Michael D. Cameron, Christopher L. Haga, Laura H. Rosenberg, Marie Lafitte, Derek Duckett and Donald G. Phinney of TSRI.

Northwestern scientists were able to rapidly design the novel small molecule MW108 to selectively disable the protein kinase because of Northwestern's premier structural genomics programs, Watterson said.

Anderson and Valerie Grum - Tokars, a junior structural biologist on the team, developed a three - dimensional structure of human p38 MAPK, enabling the chemists to design and synthesize novel drug - like small molecules that would disable it.

We have been fortunate to work in collaboration with the pharmaceutical company Pharmaxis, which is designing novel and highly selective small molecules that will allow the establishment of normal tissue architecture after wound repair.»

His lab is designing small peptides that target the seeds and mimic regions of «chaperone» molecules, which usually bind to proteins and help them to fold correctly.

The attraction of large - scale compound screening for life science researchers lies mainly in the technical challenge of assay design and the use of small - molecule effectors for hypothesis - driven research.

«The innovative design and optimization of these contrast agents has the potential to lead to the development of other tissue - specific small molecule contrast agents.

To test DDX3's druggability, the team chose to design its own small molecule rather than screen libraries of molecules already created.

Dr. Disney and his group studied the structure of the RNA that resulted from the C9ORF72 mutation, and then designed the lead small - molecules.

Designed to mimic antibodies, the small molecules bind the virus in a similar manner.

Led by Laboratory Fellow Dr. Julia Laskin, scientists at Pacific Northwest National Laboratory have now found a way to carefully design technologically important interfaces by soft landing active molecules onto a small solid - state electrochemical cell.

This study therefore focused on the design and development of a series of single small molecules containing multiple guanide or biguanide groups (Table 2, Figure 20)[100].

The computationally re-designed receptors provide a modular platform that could theoretically allow design and use of highly specific receptors for most small molecules.

The Center for Predictive Medicine recognizes the challenges of translational research such as in designing and implementing high - throughput screens and assessing small molecules and potential vaccines for their efficacy in small animal models of disease.

Once the Vanderbilt small molecule library has been screened for potential modulators of the Y4 receptor, I will use the results to design efficient and accurate descriptors that can be used with artificial neural networks to predict activity at the Y4 receptor based on a small molecule's structural properties.

«This tells us that it is possible to design a small - molecule inhibitor that could powerfully disrupt the interaction between the toxin and the receptor,» said Brunger.

Dr. Appel's primary areas of expertise are thermochemical measurements, electrochemistry, catalyst design and synthetic chemistry, small molecule spectroscopy, and mass spectrometry.

Practically speaking, this knowledge of how the toxin recognizes the double receptor could lead to a rational basis for designing small - molecule inhibitors to this recognition step,» he said.

An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.

The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.

Other companies, including the Swiss drug giants Novartis and Roche, along with Boston's Paratek Pharmaceuticals, are developing ingestible small - molecule drugs designed to increase the inclusion of SMN2 «s exon 7.

Principal investigator Livia Eberlin, a chemistry professor at the University of Texas at Austin, explained that it's designed to gently extract small molecules from the surface of living tissue using nothing but a suspended droplet of water.

When the goal is to block the expression of genes with molecules of siRNA (small interfering RNA), the synthetic DNA can be designed with a section complementary to the RNA so that the RNA will loosely attach to it.

Further the Meiler laboratory develops a structure - based drug design module for ROSETTA and docking protocols particularly suited for docking small molecules into comparative models.

Specifically we seek to de novo design proteins to bind small molecule ligands with high selectivity.

As reported online in PLoS One on October 3, Hopkins colorectal cancer specialists John Abraham, Ph.D., and Stephen Meltzer, M.D. - working with the notion that small molecules generally make better treatment packages - designed small bits of protein only 10 amino acids long as the foundation for their drugs.

Our system is modular and PBPs can theoretically be designed to bind most small molecules.

Given our extensive experiences in neuronal differentiation of hESCs [6], [7], [8] and the potential application of hESC - derived neurons in cell replacement therapies for neurodegenerative diseases, we designed a set of experiments aimed at developing a hESC - based automated assay for screening small molecules that have differential toxicity to hESC - derived NSCs and their differentiated neural progenies.

GLAAS, which stands for «GLA Adjuvant Systems,» is a discovery platform that is designed to work in vivo and is based on a synthetic small molecule, Glucopyranosyl Lipid A (GLA).