Sentences with phrase «designed small molecule inhibitors»

He went on to a postdoctoral position with Dr. Iwao Ojima evaluating anti-tubercular compound series that inhibit the cell division protein FtsZ and screening computationally designed small molecule inhibitors of Botulinum neurotoxin.

«If we could design a small molecule inhibitor that would look like heme - iron but would actually clog up a key metabolic pathway in bacteria, we may be able to get around the problem of antibiotic resistance,» suggests Dr. Mason, who adds that he and Dr. Justice plan to use the new five - year NIH grant to further studies of just such an inhibitor.

Not exact matches

«This tells us that it is possible to design a small - molecule inhibitor that could powerfully disrupt the interaction between the toxin and the receptor,» said Brunger.

Practically speaking, this knowledge of how the toxin recognizes the double receptor could lead to a rational basis for designing small - molecule inhibitors to this recognition step,» he said.