The result indicates that T cells and HLA, which together regulate much of the body's immune response, gang up in a unique way to
destroy narcoleptics» hypocretin cells, the team reports online this week in Nature Genetics.
Not exact matches
Further sleuthing revealed that the cells that normally produce it in the brain seem to have been
destroyed in
narcoleptics.
In
narcoleptic patients, the mechanism that makes the hormone is intact, but the cells are missing, suggesting that something
destroys them.
They found that the
narcoleptics in the study shared a version of another gene that tells T cells — the immune cells that
destroy intruders — how to react to the pathogens that HLA molecules bring them.