A number of mechanisms are responsible for decreased insulin secretion or resistance, but most involve
destroying islet cells, the cells of the pancreas that produce insulin.
Other developing therapies for type 1 diabetes either target the autoimmune condition or look to replace
the destroyed islet cells, but not both together.
Not exact matches
Usually, the body's own immune system — which normally fights harmful bacteria and viruses — mistakenly
destroys the insulin - producing (
islet, or
islets of Langerhans)
cells in the pancreas.
Once a significant number of
islet cells are
destroyed, you'll produce little or no insulin.
Diabetes researchers are considering various replacements for insulin injections: Transplanting new pancreatic
islet cells that make insulin, coaxing the patient's own
islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from
destroying the rest of their pancreatic
islets.
In type 1 diabetes, the immune system attacks and
destroys insulin - producing
cells in the
islets of the pancreas.
* In type 1 diabetes, the insulin - producing
cells in the Langerhans
islets of the pancreas are
destroyed because they are attacked by the body's immune system (formation of
islet autoantibodies against structures of the beta
cells).
The
islet cells in these animals are
destroyed and can not produce insulin.
Diabetes occurs when pancreatic
islet cells called beta
cells are
destroyed.