The only species Onstott has observed in action are nematode worms; he could see them squirming under a microscope, and took
detailed electron microscopy images of their hundredth - of - an - inch - long bodies.
To better understand how ISRIB activates and stabilizes eIF2B, Walter and his colleagues turned to Frost, a leading expert in ultra — high resolution cryo -
electron microscopy, to obtain
detailed 3D
images of ISRIB bound to ten eIF2B components.