Sentences with phrase «detected in the tumor»

In 89 % of patients, at least one genetic change detected in the tumor was also detected in the blood.

In contrast, no PCR product was detected in tumors from mice treated with trastuzumab alone.

«These tiny cells are very difficult to detect in a tumor,» she says.

Not exact matches

The focus of those hopes is the liquid biopsy: a test that could detect and analyze a solid tumor from biomarkers in the bloodstream or other easily sampled body fluids, such as saliva.

While the latter has a reputation for being hard to isolate, she explains that even degraded RNA generally contains enough intact sequence to analyze — provided investigators can detect the scarce tumor signals against the immense background of other RNA molecules in a sample.

Paweletz and his colleagues are now developing a PCR - based test to detect drug resistance mutations in lung tumors.

Nor are x-rays good at detecting tumors in dense breast tissue, which also reads as white; many women younger than 50 have dense breasts.

A team of researchers has taken a major step toward one of the hottest goals in cancer research: a blood test that can detect tumors early.

He is now fashioning the lab's multidots — tiny crystalline beads encapsulated in a special coating — into an actual product to detect multiple biomarkers on tumor cells.

In blood samples from 1005 patients with eight types of tumors that had evidently not yet metastasized, the test detected between 33 % and 98 % of cases, depending on the tumor type (see graph, above).

In contrast, our blood - based test is minimally invasive, inexpensive, and more sensitive, thus suitable for large population screening to detect early - stage tumors.»

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

The company is also working on a similar test in solid tumors for early diagnosis of relapse, and is developing tests that will help diagnose some lymphomas that are notoriously tricky to detect.

The test detects a combination of five tumor proteins that appear to be a reliable signature of the disease, the researchers report in the May 24...

«We did not detect any clear change in the long - term time trends in the incidence of brain tumors from 1998 to 2003 in any subgroup,» the researchers wrote in the paper, which was published online Thursday in the Journal of the National Cancer Institute (JNCI).

Instead, researchers told the European Breast Cancer Conference that their findings suggest that extending screening programs to older women results in a large proportion of women being over-treated, and at risk from the harmful effects of such treatment, because these women were more likely to die from other causes than from any tumors detected in the early stages of growth.

The new test uses a highly sensitive gene mutation detection method that is based on the partitioning of DNA into droplets to detect specific circulating tumor DNA mutations and RNA variants in whole blood.

For example, just before von Eschenbach arrived, NCI had agreed to fund a now - $ 350 million screening trial to see if spiral computed tomography (CT) scans could detect lung tumors missed by x-ray imaging in former smokers.

The reduction in the number of potentially unnecessary biopsies appears to have occurred at the cost of detecting fewer intermediate risk PCa tumors.

They report that the test can detect significant drops in the metabolic activity levels of all three types of tumors within 72 hours when exposed to an effective drug whereas tumors that were resistant to a drug show no change.

New research led by Li Ding, Ph.D., of Washington University School of Medicine in St. Louis, shows that current approaches to genome analysis systematically miss detecting a certain type of complex mutation in cancer patients» tumors.

The approach was most successful in making a difference in samples from the two patients in which the smaller - sized tumor DNA was not readily apparent, which may represent patients with low tumor burden and previously difficult to detect circulating tumor DNA.

The work also reinforces the importance of finding tumor cell clusters in the blood as a mechanism of detecting cancer metastasis earlier.

«This development has the potential to enable earlier detection of solid tumors through a simple blood draw by substantially improving our ability to detect very low quantities of circulating DNA derived from tumor cells,» says corresponding author Hunter Underhill, M.D., Ph.D., who initiated the research while in the lab of senior author Jay Shendure, M.D., Ph.D., a professor in genome sciences at the University of Washington.

Ben Stanger, MD, PhD, a professor in the division of Gastroenterology, and first author Ravi Maddipati, MD, an instructor in the division of Gastroenterology, say that these results may prove useful in designing better targeted therapies to stop tumor progression and provide an improved non-invasive method for detecting early disease states in this highly lethal cancer.

To see if PGD and the pentose phosphate pathway were tied to the epigenetic changes the researchers had detected in distant metastases, they treated tumor cells from different sites in a single patient with the drug 6 - aminonicotinamide (6AN), which is known to inhibit PGD but is not used in humans because of its severe side effects.

In the second study, researchers examined whether aspirin is associated with breast density, which is a widely accepted risk factor for both estrogen receptor minus (ER --RRB- and estrogen receptor positive (ER +) breast cancers, and can be a key factor in detecting tumors during routine mammogramIn the second study, researchers examined whether aspirin is associated with breast density, which is a widely accepted risk factor for both estrogen receptor minus (ER --RRB- and estrogen receptor positive (ER +) breast cancers, and can be a key factor in detecting tumors during routine mammogramin detecting tumors during routine mammograms.

Using a fluorescent protein to detect Rgs16 expression, the investigators found that this gene is induced by pancreatic tumor formation starting from its earliest manifestation as ductal neoplasm all the way to advanced solid tumor in a spatially and temporally coincidental manner.

Northwestern University scientists now have demonstrated a simple but powerful tool that can detect live cancer cells in the bloodstream, potentially long before the cells could settle somewhere in the body and form a dangerous tumor.

The MRI imaging detected metastatic tumors, including micrometastases, in lung, liver, lymph node, adrenal gland, bone, and brains of the mice.

Curious about the possibility of circular RNAs contributing to cancer, Pandolfi and his colleagues set out to see if they could detect relevant changes in tumors known to harbor distinct fusion proteins, which result when different chromosomes abnormally join together, melding two separate genes into a new centaur - like gene.

In the past few years, Vogelstein and Kinzler have shifted away from discovering new cancer genes to a less glamorous pursuit: using genetic tests to detect common tumors as early as possible, when they are easiest to cure.

Currently, in another study, the researchers are focused on detecting circulating tumor cells in the blood of patients with a diagnosis of breast cancer.

One of the candidates for this elastography, a variant of echography whereby the difference in the rigidity of the tumor and healthy tissue can be used to detect cancer.

Deep convolutional networks are all the rage at Google, Facebook, Apple and other Silicon Valley companies seeking to automatically label images, translate speech to text, detect pedestrians in videos and find tumors in breast scans.

Siva Vanapalli, an associate professor in the Department of Chemical Engineering, at Texas Tech University, recently received two grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to study the movement of tumor cells throughout the body and new methods of detecting cancer cells.

The technique is currently being tested in a number of clinical applications, including imaging breast tumors, detecting skin cancer, and tracking blood oxygenation in tissues.

Now, MIT engineers have developed a far more sensitive way to reveal ovarian tumors: In tests in mice, they were able to detect tumors composed of nodules smaller than 2 millimeters in diameteIn tests in mice, they were able to detect tumors composed of nodules smaller than 2 millimeters in diametein mice, they were able to detect tumors composed of nodules smaller than 2 millimeters in diametein diameter.

In humans, colon cancer often spreads to the liver and forms small tumors that are difficult to detect, similar to ovarian tumors.

This model showed that in order to detect tumors 5 millimeters in diameter or smaller in humans, the researchers would need to improve the system's sensitivity by at least one order of magnitude.

They detected the presence of an enzyme that can induce tumor metastasis, MMP - 2 (matrix metalloproteinase - 2) in mice with cancer.

By combining these two refinements, the researchers were able to enhance the sensitivity of the sensor 15-fold, which they showed was enough to detect ovarian cancer composed of small tumors (2 millimeters in diameter) in mice.

They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end caps» on chromosomes, which indicates prematurely aged cells.

Although the existence of ChHV5 has been known for more than 20 years, the inability to grow the virus in the laboratory hampered understanding of how it causes tumors and the development of blood tests to detect the virus.

In a study of 124 patients with advanced breast, lung, and prostate cancers, a new, high - intensity genomic sequencing approach detected circulating tumor DNA at a high rate.

MRI and computed tomography (CT) scans can be effective in finding larger tumors, but a patient's prognosis is poor by the time a tumor is detected.

This innovative approach — using high - intensity sequencing to detect cancer from circulating tumor DNA in the bloodstream — heralds the development of future tests for early cancer detection.

Importantly, without any prior knowledge from the analysis of tumor tissue, 76 % of «actionable» mutations (genetic changes that can be matched to an approved targeted therapy or one being tested in clinical trials) detected in tissue were also detected in blood.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

So, for example, at the University of California in San Francisco they are trying to engineer E. coli so that it can detect cancer cells, it can invade tumors, and then once it's inside they can release toxins; and so they are putting in all sorts of genes from other bacteria to assemble this, you know, this sort of synthetic E. coli that could become basically a cancer torpedo.