In our study of primary epilepsy, in English Springer Spaniels, Vizslas, and research Beagles the first step will be to
determine the mode of inheritance for each breed (simple recessive, simple dominant, sex - linked, or polygenic).
They donate genetic material by swabbing the inside of a dog's cheek or drawing blood and occasionally do test breedings to help
determine mode of inheritance for some diseases.
For many breeds and many disorders, the studies to
determine the mode of inheritance or the frequency in the breed have not been carried out, or are inconclusive.
Renowned ophthalmologist Dr Kirk Gelatt from the University of Florida is heading an on - going research study to isolate the gene,
determine mode of inheritance and hopefully develop a test.
This study is designed to determine the incidence of BCSL in the breed, to
determine the mode of inheritance if a single gene is involved, and identify candidate genes for further investigation.
This study is designed to determine the incidence of SCC in the listed breeds, to
determine the modes of inheritance and identify DNA variants that put horses at risk for this cancer.
Not exact matches
It is through the international cooperation
of many owners and breeders who submitted information that a
mode of inheritance has been
determined.
However, in order to develop such programs the
mode of inheritance needs to be understood and tests to
determine carrier status must be developed.
The
mode of inheritance has not been
determined precisely but the fact that dogs heterozygous for the KRT71 mutation do not have curls and also the occasional occurrence
of dogs with curly hair in breeds with typically straight hair suggests that the curly hair is inherited in a recessive or incompletely dominant
mode.
Before a disease is listed by ACVO, they
determine whether the disorder is or is probably inherited, though the
mode of inheritance may remain unknown.
The condition is rare but is seen more commonly in Staffordshire bull terriers in which pedigree analysis supports a hereditary etiology for the condition but is insufficient to
determine the exact
mode of inheritance, [148, 149].
The
mode of inheritance has been
determined to possibly be, autosomal recessive in Keeshonds16, polygenic with one gene
of major influence in Belgian Tervurens17, and polygenic recessive in Golden Retrievers.18 Once the
mode of inheritance is
determined within a breed, we will
determine the best technique to try and find a genetic marker linked to epilepsy gene (s) in each breed.
Many are found to be heritable and these can be both congenital or acquired, however the exact
modes of inheritance has not been precisely
determined for all forms
of heart disease.
To date, researchers at UC Davis School
of Veterinary Medicine and the Veterinary Genetics Laboratory have
determined that «a recessive
mode of inheritance in Haflingers explains some
of the genetic components involved in the development
of this cancer.