Sentences with phrase «develop better animal models»

The UCSF TCORS also has two developmental projects — one on risk perceptions of smoking by older Americans, and another to develop better animal models of the cardiovascular effects of secondhand smoke and exposure to other tobacco products, said Glantz.

Not exact matches

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Researchers at the University of Minnesota have developed an animal research model for facioscapulohumeral muscular dystrophy (FSHD) to be used for muscle regeneration research as well as studies of the effectiveness of potential therapies for FSHD.

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.

Brendan Wintle at the University of Melbourne, Australia, has developed an alternative model that includes data on previous searches in remote regions, as well as aspects of the animal's biology and behaviour.

When using a well established model of colorectal cancer, the researchers observed that dietary emulsifier consumption was sufficient to make the animals more susceptible to developing colonic tumors because this created and maintained a pro-inflammatory environment associated with an altered proliferation / apoptosis (cell death) balance.

These findings are promising for developing a preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, including altering the course of the disease.

Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves» disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology.

Understanding cattle movement patterns as well as the connectivity of the various sectors of the U.S. cattle industry and incorporating these in the models would allow USDA Animal Plant Health Inspection Service (APHIS) Veterinary Services (VS) to develop more effective regulations and control strategies for various animal diseases, including boviAnimal Plant Health Inspection Service (APHIS) Veterinary Services (VS) to develop more effective regulations and control strategies for various animal diseases, including bovianimal diseases, including bovine TB.

We carry out translational research programmes to develop infectious disease vaccines, therapeutics and diagnostics using animal models of tuberculosis, influenza, HIV / AIDS, Clostridium difficile, meningococcal disease, chlamydia, burkholderia and anthrax, as well as emerging viral diseases such as Crimean Congo haemorrhagic fever.

We recently developed such an animal model and propose to use it to study the role of complement in AMD as well as develop a gene therapy.

To take a finding in basic research, such as identifying a mutant protein that drives a particular cancer, and develop a drug that inactivates the protein and performs well in cells in the lab and in animal models can take years, if not decades.

To achieve this, I am developing novel cellular and animal models (like the one proposed here) that better reflect the new biological insights stemming from human genetics.

His research interests are focused on the molecular genetics of the inherited myopathies and neuromuscular junction disorders and the study of animal models of these disorders as a means to understand their pathophysiology as well as to develop means to monitor disease progression and therapeutic interventions.

Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.

We intend to develop a quantitative, detailed and cohesive definition of neuronal susceptibility to degeneration in the cerebral cortex, by extending data on Alzheimer disease to other dementing disorders as well as animal models of age - related illnesses, and by defining the key neurochemical and morphological characteristics linked to relative vulnerability (or resistance to degeneration) of identified neuronal populations.

In addition, the Fletcher group investigates immunity using the mouse model and aims to develop animal models of TB disease better able to predict TB vaccine efficacy in clinical trials.

Moreover, knock in animal models for syngeneic studies and allowing us to isolate transgenic armed effector cells are developed in order to show proof of concept for the diverse applicability of our modular targeting systems including for tumor diseases, autoimmune diseases, GvHD, transplantation / rejection as well as viral infections.

They also developed their art skills by drawing sketches of their animals and then making a model of it using chicken wire, as well as creating a representation of it's habitat.

Animal models are necessary to develop improved diagnostics and therapeutics, as well as understanding the basic pathophysiology of common human laryngeal diseases.

The emphasis is on developing intellectual abilities and research skills through investigations of infectious diseases of food - producing, companion, and aquatic animals, as well as animal models for human disease.

After all, Nintendo has partnered with IAP master DeNA to develop its mobile games and the IAP model fits the franchises very well — Animal Crossing in particular.