Sentences with phrase «to develop drug resistance»

These research collaborations have the power to answer questions critical to improving cancer outcomes, such as how tumors develop drug resistance, and what treatments are most effective against particular genomic traits.

For example, bacteria would typically develop drug resistance by evolving a mutation that breaks down the drug.

Meanwhile, pediatric pulmonologist Luke Hoffman at the University of Washington has found that some bacteria can develop drug resistance in response to an environmental change, without exposure to any antibiotics.

Antibiotics may prolong life, but the drugs often fail to cure the infection because the bacteria quickly develop drug resistance.

Professor Cowman has been integral to the global malaria research effort, leading studies into how the Plasmodium parasites that cause malaria develop drug resistance as well as understanding the biology of how malaria parasites invade and remodel red blood cells in humans.

The strategy would take advantage of parasite refugia — host populations that have not been treated with drugs, thereby serving as «safe zones» where parasites don't develop drug resistance.

«This might be explained if these people have already developed drug resistance to AZT» says Gazzard.

Unfortunately, in most patients the melanoma recurs within a year because the tumor cells develop drug resistance.

In strains of tuberculosis that have developed drug resistance mutations, researchers have identified a secondary pathway that can be activated to reinstate drug sensitivity.

«This is because most patients lack actionable mutations and, even among those who do have such molecular alterations, most either fail to respond to the targeted therapy or rapidly develop drug resistance.»

Patients with non-small cell lung cancer (NSCLC) often respond to standard chemotherapy, only to develop drug resistance later, and with fatal consequences.

Dr. Lucas Hoffman was quoted in Discover Magazine in an article entitled «Hard Living Breeds Superbugs» regarding his finding that some bacteria can develop drug resistance in response to environmental change.

They used antibiotics to screen for «hypermutable» strains that quickly develop drug resistance.

Often people on HAART go through such a window of intermediate drug concentrations when they don't take their drugs as prescribed, and develop drug resistance as a result.

The study in Oncotarget, by revealing biological mechanisms by which RAF - fusion tumors develop drug resistance, suggests a possible solution: using a combination of drugs to inhibit downstream signals along two cancer - driving pathways, thus bypassing the difference in how RAF inhibitors succeed against CRAF - fusions compared to BRAF - fusions.

While the prognosis for kidney cancer that has not spread is good, patients with advanced or metastatic cancer will develop drug resistance.

Moreover, cancer cell genomes rapidly evolve in response to environmental pressures, a feature that enables the cells to develop drug resistance.

«This should greatly improve our understanding of the genomics of bladder cancer, how these tumors respond to drugs, and how they develop drug resistance.

However, as a result of use and misuse of antibiotics (such as using the wrong drug, or not completing the full course of treatment) bacteria can develop drug resistance (known as acquired drug resistance).

Professor Michael Lisanti, who designed the study, explained: «We now know that a proportion of cancer cells escape chemotherapy and develop drug resistance; we established this new strategy to find out how they do it.

The results demonstrate that M. circinelloides can develop drug resistance two different ways, either stably through permanent mutations or transiently through reversible epimutations.

As we improve the resolution and accuracy of our analyses of genetic variation, we'll be able to delve deeper into key scientific questions like how populations of Plasmodium parasites are evolving, migrating to different locations and developing drug resistance.

It takes strong drug pressure on a parasite species to encourage it to develop drug resistance.