Sentences with phrase «develop early onset»

Approximately 40 % of American pets are overweight and develop early onset arthritis or worse than expected arthritis because of their weight.

Not exact matches

It may lead to the early onset of menarche and early development of breast tissue in developing girls.

«Adolescence is a critical risk period for initiation of alcohol use, and earlier onset of drinking is associated with greater risk of developing alcohol abuse and dependence,» said Dr. Gale Burstein, Erie County Commissioner of Health.

They also believe that by measuring a patient's dark adaptation response time they have developed a tool that can help track the onset or progression of the disease as well as measure the effectiveness of drugs that are in development to treat the disease early on.

The odds of any DeMoe harboring the mutation are 50 — 50, and if the mutation is present, the chances of developing early - onset Alzheimer's — the type that erodes memory before age 65 — are 100 percent.

(A rare early - onset form of the disease guarantees a person develops Alzheimer's at a young age after inheriting even one copy of certain genes.)

The fish oil study examined a different question: In children at risk for type 1 (juvenile onset) diabetes, does the consumption of fish oil reduce their risk of developing early signs of the disease?

The authors anticipate that health care providers will use the early - detection biomarkers to test for their presence and levels in blood from pancreatic cancer patients and blood drawn from individuals with a high risk of developing pancreatic cancer, including those who have a first - degree relative with pancreatic cancer, are genetically predisposed to the disease, or who had a sudden onset of diabetes after the age of 50.

BD is commonly preceded by early depression or other symptoms of mental illness, sometimes years before BD develops, as indicated by onset of mania or hypomania.

In general brigatinib is well tolerated but in a small proportion of cases early onset pulmonary symptoms can occur in which patients develop rapid shortness of breath and oxygen dependency.

Carriers of the apolipoprotein (ApoE) ɛ4 allele are at greater risk for developing late - onset Alzheimer's disease (AD), develop AD at an earlier age, and experience a more severe cognitive decline and shorter survival times.

As part of the study, co-authors Thad Stappenbeck, MD, PhD, professor of pathology and immunology, and Paul Allen, PhD, the Robert L. Kroc Professor of Pathology and Immunology, worked with mice they genetically altered to develop a condition similar to very early onset IBD.

Genome - wide association analysis comparing affected and unaffected PWC with the SOD1 mutation identified a haplotype within the gene «SP110 nuclear body protein'that was associated with increased risk of developing DM and early age of onset.

The APOE4 trial builds on another trial of an anti-amyloid drug in 300 members of a Colombian family who carry a gene mutation that places them at high risk of developing an early - onset form of Alzheimer's disease.

Individuals who carry this ε4 variant of APOE are at increased risk for developing Alzheimer's disease, early age of Alzheimer's disease onset, and more rapid progression of Alzheimer's disease symptoms.

In the past, men who developed early - onset testicular cancer often had no offspring as a result of the treatment they received, although the odds that they will are better now.

While the colorectal and breast cancer patients had no unusual CNVs, 7 % of those with early - onset testicular germ cell tumors — which are the vast majority of all testicular cancer cases — had a CNV that had developed de novo, that is not inherited directly from their parents but the result of a change to a sperm or egg cell.

Clinical trials scheduled to begin later this year will test this idea by giving anti-amyloid drugs to people genetically predisposed to early - onset Alzheimer's disease before they develop symptoms.

Individuals with Down Syndrome are more likely to develop early - onset Alzheimer's disease than the general population.

Our approach differs from that adopted by Charlesworth [61], [62], who developed mathematical models to formalize the mutation accumulation hypothesis [63] that, together with the antagonistic pleiotropy hypothesis [3], [64], may be used to show how senescence can evolve by the accumulation of deleterious alleles through mutation - selection balance at frequencies that increase with their age of onset; such mutations enhance reproductive performance early in life but diminish survival late in life through physiological trade - offs.

It is important to understand pubertal timing as early pubertal onset can influence the risk of developing a number of health disorders such as obesity and diabetes in adulthood.

Furthermore, whereas XpdTTD / TTD mice developed kyphosis earlier than wt animals (onset ~ 3 mo versus 12 — 20 mo), compound heterozygous XpdTTD / † XPCS mice did not (Figure 3B).

Sharma's lab at Women & Infants Hospital has developed a test that, based on initial data, can detect clumps of the protein TTR in blood serum as early as 12 weeks into pregnancy, which is eight weeks before the typical onset of the condition.

They found that when an MS - like disease was induced in mice genetically engineered to be deficient in Tob1, the mice had significantly earlier onset compared with wild - type mice, and developed a more aggressive form of the disease.

The goal of our study is to develop a novel imaging technique to quantitatively detect earliest onset of glaucoma for use as a potential screening method.

Familial or early - onset Alzheimer's disease is inherited and develops in people between the ages of 30 and 60.

Conclusions: Our findings demonstrate that disruption of Bscl2 specifically in developing adipocytes is sufficient to cause the early - onset generalised lipodystrophy observed in patients with mutations in BSCL2.

They also believe that by measuring a patient's dark adaptation response time they have developed a tool that can help track the onset or progression of the disease as well as measure the effectiveness of drugs that are in develpoment to treat the disease early on.

Developing cancer before age 50, also known as early onset cancer, is often a strong indication that a patient has a genetic mutation.

About Site - Early onset Alzheimer's only affects about 5 percent of people who develop Alzheimer's and begins prior to 65 years of age.

The medical community is quite excited about Dr. Trojanowski's findings because, if these proteins are indeed an early indicator that Alzheimer's will develop, it would be possible to give patients preventative treatments to delay or prevent the onset.

Developmental or Early Onset Cataracts develop from hereditary traits but can also be caused by diabetes mellitus or trauma as well as infection or toxins.

The person who worried about the «38 — 57 % of those dogs evaluated early where they predict CHD will develop, but doesn't...» isn't adding «at two years of age», and again ignores the much worse situation where at least an equally high percentage of OFA - normal dogs might develop late - onset DJD and / or pass on many bad genes to offspring.

But when they eat only (or primarily) dry foods, cats can develop problems such as bladder stones, bladder irritation or cystitis, constipation and early - onset kidney disease.

«Pet obesity significantly increases the danger of developing major health problems such as diabetes, arthritis and heart disease and can also bring about the onset of these chronic diseases much earlier.

Whereas most dogs show the same ophthalmoscopic abnormalities the age at which these abnormalities develop varies considerably between breeds and genetically different forms of PRA can be broadly divided into early - and late - onset forms.

Irrigation was one of the earliest technologies developed 9000 years ago to offset droughts in the Fertile Crescent, triggered by onset of Holocene warming.

Preeclampsia that develops before week 32 is considered early onset and carries with it an elevated morbidity risk.

The onset of Dysthymia is considered to be early if it develops before age 21 and late if it develops after the age of 21 years old.

This pathway is characterized by three elements: the onset of conduct problems (such as developmentally excessive levels of aggression, noncompliance, and other oppositional behaviour) in the preschool and early school - age years; a high degree of continuity throughout childhood and into adolescence and adulthood; and a poor prognosis.1, 2 The most comprehensive family - based formulation for the early - starter pathway has been the coercion model developed by Patterson and his colleagues.3, 4 The model describes a process of «basic training» in conduct - problem behaviours that occurs in the context of an escalating cycle of coercive parent - child interactions in the home, beginning prior to school entry.

However, some individuals have onset of SUD early in adolescence, develop multiple SUD diagnoses, and have severe persistent courses [1, 2].

It seems that onset of a major depression disorder before 30 years of age in parents increases the risk of their children developing depression quite early during childhood [33], [34].