Sentences with phrase «develop more inflammation»

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These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Pressure ulcers affect more than 2.5 million Americans annually and patients who have spinal cord injuries that impair movement are more vulnerable to developing them, said senior investigator Yoram Vodovotz, Ph.D., professor of surgery and director of the Center for Inflammation and Regenerative Modeling at the Pitt School of Medicine.

The scientists transferred the twins» gut bacteria to mice predisposed to develop a disease that mimics MS. Twelve weeks after the transplant, about 40 percent more mice with gut microbes from a twin with MS developed brain inflammation compared with mice that got gut microbes from a twin without disease.

Rheumatoid arthritis patients are likelier than the average person to develop chronic kidney disease, and more severe inflammation in the first year of rheumatoid arthritis, corticosteroid use, high blood pressure and obesity are among the risk factors, new Mayo Clinic research shows.

Pathogenic bacterial infections like salmonella and E. coli are huge problems in developing countries because they are much more harmful to people suffering from malnutrition, leading to chronic diarrhea and inflammation.

After downing his bacterial concoction, he soon became far more ill than he had expected, vomiting and developing stomach inflammation.

10 Possible explanation: Pregnant women tend to develop gingivitis (inflammation of the gums) as hormonal shifts make the tissues more sensitive to irritation.

Bettcher said the new findings could possibly serve as the focus of more in - depth studies aimed at developing a blood test to detect inflammation biomarkers years before symptoms of Alzheimer's appear.

Chronically sleep deprived people are more likely to develop other health problems such as increased inflammation and high blood pressure.

Grn − / −, but not Grn + / − mice, develop progressive gliosis, inflammation, and lipofuscinosis in several brain regions that first becomes detectable around 6 — 7 months of age and is more strongly elevated by 12 months (Ahmed et al., 2010; Yin et al., 2010; Wils et al., 2012; Filiano et al., 2013; Götzl et al., 2014).

«Work needs to be done to uncover the specific factors that contribute to brain inflammation, but finding a way to reduce inflammation's harmful effects and increase its helpful effects could enable us to develop a new treatment much more quickly,» Meyer concluded.

A healthy microbiome means a person has a better immune system, less risk of developing an auto - immune disease, reduced inflammation, are more insulin sensitive, and perhaps can be happier with less depression and anxiety, since studies do show a «brain - gut» connection.

To understand more about why people develop Alzheimer's disease, Dr. Lewis recommends looking to the various causes of inflammation, which can include environmental toxins, stress, poor nutrition, lack of sleep and bacterial and viral infections.

I have increasingly developed more and more food sensitivities that result in swelling finger joints and eruptions on facial skin, and I would suspect general inflammation.

Factors like this, in addition to culprits like undiagnosed food allergies and foods that are loaded with sugar and fat can cause inflammation to develop throughout the entire body, and more often than not the result of this will become evident on the skin.

Chronic stress while the brain and central nervous system are still developing can create ongoing inflammation and set the stage for autoimmune disease to more easily trigger later in life.

By eating more of certain foods, many of which are perfect in smoothie recipes, and avoiding bad foods, you can lower your overall inflammation and reduce your risk of developing some of these diseases.

Experiments in Muc1 knockout mice and mice with Muc1 knockdown have shown that under Helicobacter infection, mice deficient in Muc1 develop far more cancer - promoting inflammation than normal mice.

Pets that eat hard kibble develop this tartar and inflammation more slowly.

In more serious — but fortunately, less common — cases, dogs can develop a type of kidney disease called Lyme nephritis, which is often fatal, even in young, healthy dogs, as well as myocarditis — inflammation of the heart muscle — and neurological disease.

Dogs and cats are more likely to develop heat and inflammation of the ears, head, neck, and feet than of the eyes and nose.

Because dogs» eyes develop more serious inflammation than human eyes after cataract surgery, they must receive treatments (a combination of pills, eye drops, and ointments) several times daily for four to six weeks after this surgery.

This is more often seen in older rabbits, as these have had time to develop molar spurs, or molar root problems that can cause inflammation or even develop into infections that spread to the sinuses.

The healthy mice developed low - grade intestinal inflammation and a metabolic disorder that caused them to eat more, becoming obese, hyperglycemic, and resistant to insulin.