Sentences with phrase «develop small molecule drugs»

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

And Weinstock notes that if researchers can determine how the parasites trigger the shift in microbe composition, «we may be able to bypass the worms and develop a small molecule drug to get the effect in a safe way.»

Developing small molecule drugs for Type II diabetes and Osteoarthritis / inflammation based diseases.

Not exact matches

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

In principle, if further tests bear out the protective effects of the two antibodies, then optimized versions of them, or small - molecule drugs that hit the same target, could be developed as treatments for rhinovirus infections.

Anderson and Valerie Grum - Tokars, a junior structural biologist on the team, developed a three - dimensional structure of human p38 MAPK, enabling the chemists to design and synthesize novel drug - like small molecules that would disable it.

The basic problem the team faced with these and other vaccines they've developed is that the opioid drugs are small molecules, which are not recognized by the immune system.

The researchers say the next step is to develop small molecules or drugs that regulate p75 NTR to reproduce this effect and potentially serve as a therapeutic intervention for obesity and metabolic syndrome.

The scientists developed a small - molecule drug compound to prevent abnormal cellular processes caused by a mutation in the C9ORF72 gene.

The cells generated in the Zeng lab may not only provide a potential unlimited source for cell replacement therapy for Parkinson's disease, but also offer an unprecedented opportunity to develop screening models for assessing small molecule drugs and to clarify the mechanisms of disease.

Not a light read, this tome is bursting with information about monoclonal antibodies, from the history of how these therapies were first developed to new approaches such as conjugate therapy, which combines antibodies with small - molecule drugs.

«This partnership puts our mRNA Therapeutics platform in the hands of Karolinska's world - class scientists and clinical researchers to develop new drugs and therapeutic approaches that can not be done with small molecules or biologics — bringing new hope to patients with serious diseases.»

Vescor, advised by its scientific founders White and Kimmelman, whose research has shown inhibition of autophagy can dramatically impact tumor growth in pre-clinical models, will develop small molecule inhibitors of a number of protein targets at critical nodes of the autophagy cascade, perform investigational new drug (IND) enabling studies, and move these into clinical development.

I wish them well on developing (1) an antibody to detect and image glucosepane in animals (2) a small molecule drug or enzyme (catabody) to remove the glucosepane (3) luck in finding a development partner for this hypothetical glucosepane breaker.

E-Scape Bio is now developing small - molecule drugs that target the primary genetic cause of Alzheimer's disease by correcting adverse effects of the apolipoprotein E4 (apoE4) gene.

Because LINGO1 has be shown to have a negative impact on neuronal development and survival, inibiting it with a small molecule drug may provide an effective approach for developing a treatment for the severe forms of essential tremor.

In another sign of growing pharmaceutical industry interest in targeted protein degradation, Celgene will pay Vividion Therapeutics $ 101 million in a four - year pact to develop small - molecule drugs for cancer, inflammation, and neurodegenerative diseases.

Other companies, including the Swiss drug giants Novartis and Roche, along with Boston's Paratek Pharmaceuticals, are developing ingestible small - molecule drugs designed to increase the inclusion of SMN2 «s exon 7.

Then for postdoctoral research I moved to Yale University, where I worked in a lab that looked at all kinds of different disease areas using the approaches of a field called chemical biology, which is using small molecules — chemicals — to probe biological systems in the hopes of developing compounds that could be new drugs.

Further the Meiler laboratory develops a structure - based drug design module for ROSETTA and docking protocols particularly suited for docking small molecules into comparative models.

Our goal is to study the molecular mechanisms by which the IL - 1R - TLRs mediate signaling, with the long - term aim of developing more effective anti-inflammatory small - molecule drugs.

She has experience in small molecule and large molecule development for both oncology and non-oncology indications and has a strong interest in developing alternative in vitro and in vivo methods to assess safety and efficacy outside of the traditional drug development paradigm.

Eventually, the team hopes that a combination of small, drug - like molecules could be developed to replace the cocktail, offering a safer and easier method of delivery.

As part of the global effort toward malaria eradication, phenotypic whole - cell screening revealed the 2 - aminopyridine class of small molecules as a good starting point to develop new antimalarial drugs.

It discovers and develops novel, small - molecule drugs for the treatment of inflammatory and autoimmune diseases, as well as muscle disorders.

Rigel Pharmaceuticals, Inc is a clinical - stage drug development company that discovers and develops novel, small - molecule drugs for the treatment of inflammatory / autoimmune diseases, as well as for certain cancers and metabolic diseases.

Vertex Pharmaceuticals is engaged in the business of discovering, developing and commercializing small molecule drugs for the treatment of serious diseases.

I am interested in Scientist position for designing and developing novel small molecules, developing new synthetic routes and process optimization, for drug discovery and development.