The fact that the subjects
developed high homocysteine «unrelated to vitamin B status» is matters.
Not exact matches
A level of
homocysteine moderately above average corresponded to a 16 per cent
higher risk of
developing Alzheimer's, while a level of active B12 slightly above average meant a 2 per cent lower risk (Neurology, vol 75, p 1408).
Several comprehensive reviews of available published scientific findings on the progression of Alzheimer's disease reveals that
high levels of the toxic amino acid
homocysteine as well as low folic and B12 levels in blood are associated with an increase in the risk of
developing Alzheimer's disease.
Research has found that individuals with the lowest levels of
homocysteine have about half the risk of
developing Alzheimer's disease compared to those with the
highest levels.
The study also found serum deficiencies in those same nutrients with
high homocysteine levels, which may be associated with hardening of the arteries, also predicted likeliness of
developing AMD.
In a sample of 1,092 men and women without dementia followed for an average of 10 years, those with
higher plasma
homocysteine levels at baseline had a significantly
higher risk of
developing Alzheimer's disease and other types of dementia.
A prospective study in 816 elderly men and women reported that those with hyperhomocysteinemia (
homocysteine levels > 15 μmol / L) had a significantly
higher risk of
developing Alzheimer's disease or dementia.