Sentences with phrase «developed mouse lines»
Dr. Rudolph's group is developing mouse lines that carry mutations found in patients with schizophrenia — specifically copy number variations, in which segments of DNA are either duplicated or deleted.
https://www.mcleanhospital.org/ Not exact matches
Their report, published May 10 in the journal Nature Communications, suggests that among more than a dozen different lines of mice developed around the world to mirror autism caused by mutations to the SHANK3 gene, Duke researchers are the first to create a mouse in which that gene has been completely eliminated.
Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»
They have since learned that as many as 40 of those lines may never be fully developed; some may even have been contaminated by mouse cells used to sustain them in the lab.
Various mouse lines have been developed to express proteins that can be used to visualize changes in concentrations of calcium, which increase when neurons become active.
Similar to their previous findings in germ - free mice, the new results showed that the immune system failed to fully develop in bacteria - deprived fish, which also had diminished abilities to process nutrients and regenerate their intestinal linings.
By rewriting a tiny portion of the mouse genetic code, the team developed a genetic line of mice with cells that could, under the right circumstances, produce a powerful protein called caspase when they start secreting p16.
GMC strategy: To develop and offer a large scale standardised and comprehensive phenotypic analysis of mouse mutants from various sources (e.g. transgenic lines, knockout mice, ENU mutants or endonuclease mediated mutations)
The researchers used a modified virus to insert genetic mutations into cells lining the mice's lungs, causing the animals to develop tumors.
In their latest study, the group conducted a genome wide screening by developing a novel primary mouse embryonic stem cell line that enhances the efficiency of CRISPR - Cas9 mediated mutations.
We are developing in vivo models for the disease in the mouse, and in vitro models starting from human pluripotent stem cell lines.
For her dissertation, Prerana developed several bacTRAP transgenic mouse lines to characterize molecularly distinct cortical pyramidal cell types, and focused on layer 2/3 pyramidal cell population in the prefrontal cortex that moderate stress induced depression related behavior.
The lab develops methods to label RNA endogenously in cell lines and mice.
Dr. Cole's project, «Mechanistic Derivation of Germ Line Mutation by Genome - Wide Mouse Tetrad Analysis,» will help define the global patterns of de novo germ line mutations and the frequencies at which such mutations occur in mice, with the long term goal of understanding the molecular mechanisms underlying germ line mutagenesis and developing strategies to prevent or treat disorders caused by such mutatiLine Mutation by Genome - Wide Mouse Tetrad Analysis,» will help define the global patterns of de novo germ line mutations and the frequencies at which such mutations occur in mice, with the long term goal of understanding the molecular mechanisms underlying germ line mutagenesis and developing strategies to prevent or treat disorders caused by such mutatiline mutations and the frequencies at which such mutations occur in mice, with the long term goal of understanding the molecular mechanisms underlying germ line mutagenesis and developing strategies to prevent or treat disorders caused by such mutatiline mutagenesis and developing strategies to prevent or treat disorders caused by such mutations.
The Sanger Institute Gene Trap Resource (SIGTR) mouse ES cell line collection was developed to provide a powerful and cost effective approach using gene trapping to create large numbers of insertional mutations that are immediately accessible to molecular characterization.
The Company develops and brings to market proprietary lines and licensed product, including, Wild Kratts, Teenage Mutant Ninja Turtles ®, Garfield, The Wiggles, Crashlings, My Girl's Dollhouse, Vrüm, WWE ®, Disney Princess ®, Minnie Mouse ®, Marvel ®, Batman ®, Superman ®, Iron Man ®, Sponge Bob ®, Sesame Street, Dora the Explorer ®, and Monster Jam ®.