Sentences with phrase «developing cell level»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

As breastfed babies poop more frequently, their levels actually drop quicker, but it can take 5 - 10 days in a full - term infant for the liver to develop a little more to properly excrete the blood - cell byproduct.

Richard Jones, M.D., professor and director of the Bone Marrow Transplant Program at Johns Hopkins, developed a now commonly used assay to study ALDH levels in individual cells.

Gandhi's research team is the first to develop a mouse model with depleted levels of a protein called augmenter of liver regeneration (ALR), which is essential for the survival of liver cells called hepatocytes.

«At the very microscopic level,» he says, «we have developed techniques like two - photon microscopy, which allows extremely detailed examinations of structures and processes within cells.»

International researchers, including those from Osaka University, developed a new method to image intracellular fatty acids at a single cell level.

The detector developed at UNH, known as DoSEN, short for Dose Spectra from Energetic Particles and Neutrons, measures and calculates the absorbed dose in matter and tissue resulting from the exposure to indirect and direct ionizing radiation, which can change cells at the atomic level and lead to irreparable damage.

This protein is expressed at relatively high levels in proliferating precursors and non-neuronal cells but down - regulated in developing neurons by a brain - enriched regulatory RNA called miR - 9.

Most importantly, these cells protected mice from developing diabetes in a model of disease, having the critical ability to produce insulin in response to changes in glucose levels.

To determine the age of the blood cells, Higgins and his colleagues developed an equation that compares glucose levels obtained by the A1C test with another method called continuous glucose monitoring.

MIT researchers have developed a way to measure white blood cell levels by imaging the cells as they flow through capillaries at the base of the fingernail.

In a recent study published in Angewandte Chemie International Edition, Associate Professor of Chemistry Wei Min's team developed a new glucose analogue that can mimic the natural glucose, and imaged its uptake as energy source by living cancer cells, neurons and tissues at the single cell level.

Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.

«We are currently developing tools in the lab to study the cell cycle and cellular morphology of Sulfolobus at the single - cell level under the microscope.

Factors such as insulin and blood sugar levels also influence whether or not adult stem cells in adipose tissue will develop into mature adipose cell.

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

As study leader Marr explains, «Since we now know which cells will develop in which way, we can isolate them earlier than before and examine how they differ at a molecular level.

The one developed by Zhang and his team, including Ph.D. student Inga Haedicke, U of T Assistant Professor Hai - Ling Margaret Cheng and two research groups (Dr. Timothy Scholl and Dr. Paula Foster) from Western University, can improve monitoring at the cellular level, which is a crucial element in measuring the effectiveness of stem and therapeutic cell treatments.

Yongyou Zhang, PhD, a Case Western Reserve research associate in Markowitz's lab and a lead author on the study, developed a test where cells glowed when 15 - PGDH levels changed.

Researchers back then found that exposure to aluminum caused rabbits» brains to develop nerve cell damage — thought to be a precursor to Alzheimer's at the time — and long - term dialysis patients with high levels of the metal developed dementia.

«We will also encourage postdocs to develop some level of independence by having more than one mentor,» says Sharon Milgram, a professor of cell and developmental biology and faculty adviser for the UNC Office of Postdoctoral Services.

Now a more fine - grained picture of adhesion mechanics is emerging, thanks to a new tool developed in Illinois in recent years called a «tension gauge tether,» which allows scientists to measure cell mechanics at the single - molecule level.

Other studies show that visceral obesity raises a person's risk of developing colon cancer, perhaps because it increases circulating levels of hormones that affect cell growth.

«We were able to develop this very novel method to go to a single neuron and manipulate how it computes» by using drugs to block neurotransmitters at the level of a single nerve cell in a frog brain, and then measuring what happens to that neuron in response to frog calls, Alluri says.

In future, it may be possible to measure BCR - ABL levels in individual cells in the clinic — this will help us identify the resistant high BCR - ABL cells and better understand how patients develop resistance to imatinib treatment with the aim of combatting this resistance to make response more durable and the treatment more effective.»

The team has been able to prove that such epigenetic alterations are associated with the increased levels of an enzyme, namely DNA methyltransferase 3A (DNMT3A), which is responsible for the acquisition of the suppressive properties of these cells that develop in the tumoral microenvironment.

Using our approach we are starting to understand how kidney disease develops at the level of a single cell.»

«We need to develop specific tools to study chemical toxicity in human reproductive cells; this will allow us to accurately assess safety thresholds for different compounds, and re-evaluate the acceptible daily intake levels to protect human health for some of them» said Professor Habert.

In contrast to studies that correlated elevated levels of IGF - 1 with the risk of developing prostate cancer, Greenberg's research showed that eliminating IGF - 1R expression in an otherwise normal mouse prostate caused the cells to proliferate and become hyperplastic.

To this end, we are developing a new multi-scale live imaging approach to characterize nuclear organization dynamics at the single cell level based on the simultaneous characterization of both the local dynamics of RNA polymerases and transcription factors and the large scale behavior of chromatin.

In the present study, the researchers have developed a mass spectrometry - based method that is sensitive and reproducible in order to measure, at steady - state conditions, absolute protein copy numbers across human tissues and cell lines and compared these levels with the corresponding mRNA levels using transcriptomics.

Only women who have previously suffered from placental malaria develop substantial levels of protective antibodies that prevent the adhesion of red blood cells to placental CSA.

When developing heart cells are exposed to high levels of glucose, the researchers found, the cells generate more building blocks of DNA than usual, which leads the cells to continue reproducing rather than mature.

«We found several distinctions between sensitive and resistant models detected at the single - cell level, which testified to single - cell sequencing potential usefulness for understanding how these cancers may develop resistance.»

Understanding the processes that restrain mutant cells from developing into tumours, and how they are breached when cancers do form will guide the development of strategies to reduce the chance of cancer development in individuals who have acquired a high level of mutations.

His role is to interact with scientists at all levels, understand and gather requirements for developing and maintaining informatics systems supporting Stem Cell Engineering.

NeuroStemcell recognizes the essential requirement to include a coherent program of both internal and open activities to promote training and networking within the consortium while maximizing synergy and interaction, and to develop the level of exchange, understanding and awareness necessary to create a critical mass of trained researchers and clinical scientists across Europe able to help the assessment of the clinical value of selected stem cell products.

May 25, 2000 Different levels of transcription factor coax immune cell progenitors down different developmental pathways Researchers from the University of Chicago provide evidence that varying levels of a single transcription factor can determine the fates of developing cells.

HHMI investigator Arul Chinnaiyan and colleagues at the University of Michigan showed that as prostate cancer develops and progresses, sarcosine levels increase in both tumor cells and urine samples, suggesting that measurements of the metabolite could aid in non-invasively diagnosing the disease.

This discovery stemmed from a novel series of tests, developed by Nakamura's laboratory, that measure energy levels in cells.

Yeast cells were developed under various disorders; the amount of red or yellow light represents the level of

In parallel studies at a broader level, he will develop microfluidic technology to precisely induce and monitor protein aggregation in living cells and organisms over time.

Below we report the experimental results for a new selective mechanism of PNB generation around clusters of gold NPs, and the evaluation of the developed mechanism at cell level for the theranostics of prostate cancer cells growing amidst normal stroma.

We have developed SCID mouse models that support high levels of engraftment with human cells and tissues to overcome these limitations.

But researchers from the University of North Carolina and NC State have now developed what could be a much more patient - friendly option: artificial cells that automatically release insulin into the bloodstream when glucose levels rise.

sorafenib induces cell death in human myeloma cell lines in a laboratory environment by preventing a certain kind of protein - level activity, an effect that also was achieved when the myeloma cells had developed a resistance to

Arafat and her team discovered that when they treated pancreatic tumors (developed in animals for the study) with thymoquinone, 67 % of the tumors shrunk significantly, and levels of inflammatory markers in the cells dropped substantially.

If not enough carbohydrate is consumed to maintain blood glucose levels for the brain, nervous system, and developing red blood cells the breakdown of glycogen for glucose results in a loss of water, which many interpret as weight loss.

Liver glycogen is broken down to release glucose if blood glucose levels fall too low, to provide glucose to the brain, nervous system, and developing red blood cells.