Sentences with phrase «developing chimeric»

Santa Monica, California - based Kite is developing chimeric antigen receptor T - cell therapy, known as a CAR T, which harnesses the body's own immune cells to recognize and attack malignant cells.

Fifteen years ago, Campana helped develop the chimeric antigen receptor that's used in Kymriah today.

Not exact matches

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

US - based pharmaceutical company Gilead Sciences entered the chimeric antigen receptor (CAR) T - cell therapy business through its acquisition of Kite Pharma, and Australian biopharma company CSL Behring acquired US - based Calimmune, a company that develops clinical - stage gene therapy solutions.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

The team developed a «chimeric autoantibody receptor,» or CAAR, that displays fragments of the autoantigen Dsg3 — the same fragments to which PV - causing antibodies and their B cells typically bind, as Payne's laboratory and others have shown in prior studies.

Some worry that such human cells, when combined with animal embryos, could develop into brain cells, sperm, or egg cells in the chimeric offspring.

The same technique — injecting pluripotent stem cells into early embryos — failed with other combinations: The scientists couldn't create rat - pig chimeras, and although they produced human - cow chimeric embryos, they did not transfer them into cows to develop into fetuses.

To do so, the engineered ESCs would be injected into developing mouse embryos, the embryos allowed to develop into chimeric mice (with a fraction of the cells in the adult mice derived from the engineered ESCs), and chimeric adults mated to produce completely transgenic offspring.

In bacteria, the ligand - PBP complex develops high affinity for transmembrane proteins such as Trg, and the chimeric Trg - HK protein allows activation of gene expression with one additional protein, a bacterial response regulator [5].

Attempts to test the intrinsic role of S1pr1 using BM chimeras were unsuccessful due to difficulties in achieving efficient reconstitution of IL7RαhiCcr6 + cells and our finding that many of the cells developing in the chimeric mice appeared activated based on CD69 expression (not shown).